Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases

Victor V. Revin; Natalia V. Gromova; Elvira S. Revina; Maria I. Martynova; Angelina I. Seikina; Nadezhda V. Revina; Oksana G. Imarova; Ilia N. Solomadin; Alexander Yu Tychkov; Nikolai Zhelev

doi:10.1155/2016/3429604

Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases

Victor V. Revin
, Natalia V. Gromova
, Elvira S. Revina
, Maria I. Martynova
, Angelina I. Seikina
, Nadezhda V. Revina
, Oksana G. Imarova
, Ilia N. Solomadin
, Alexander Yu Tychkov
, Nikolai Zhelev

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

152 Downloads (Pure)

Abstract

The composition and condition of membrane lipids, the morphology of erythrocytes, and hemoglobin distribution were explored with the help of laser interference microscopy (LIM) and Raman spectroscopy. It is shown that patients with cardiovascular diseases (CVD) have significant changes in the composition of their phospholipids and the fatty acids of membrane lipids. Furthermore, the microviscosity of the membranes and morphology of the erythrocytes are altered causing disordered oxygen transport by hemoglobin. Basic therapy carried out with the use of antiaggregants, statins, antianginals, beta-blockers, and calcium antagonists does not help to recover the morphofunctional properties of erythrocytes. Based on the results the authors assume that, for the relief of the ischemic crisis and further therapeutic treatment, it is necessary to include, in addition to cardiovascular disease medicines, medication that increases the ability of erythrocytes' hemoglobin to transport oxygen to the tissues. We assume that the use of LIM and Raman spectroscopy is advisable for early diagnosis of changes in the structure and functional state of erythrocytes when cardiovascular diseases develop.

Original language	English
Article number	3429604
Pages (from-to)	1-11
Number of pages	11
Journal	BioMed Research International
Volume	2016
DOIs	https://doi.org/10.1155/2016/3429604
Publication status	Published - 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology
General Immunology and Microbiology

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10.1155/2016/3429604

Final Published VersionFinal published version, 5.06 MBLicence: CC BY

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Revin, V. V., Gromova, N. V., Revina, E. S., Martynova, M. I., Seikina, A. I., Revina, N. V., Imarova, O. G., Solomadin, I. N., Tychkov, A. Y., & Zhelev, N. (2016). Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases. BioMed Research International, 2016, 1-11. Article 3429604. https://doi.org/10.1155/2016/3429604

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title = "Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases",

abstract = "The composition and condition of membrane lipids, the morphology of erythrocytes, and hemoglobin distribution were explored with the help of laser interference microscopy (LIM) and Raman spectroscopy. It is shown that patients with cardiovascular diseases (CVD) have significant changes in the composition of their phospholipids and the fatty acids of membrane lipids. Furthermore, the microviscosity of the membranes and morphology of the erythrocytes are altered causing disordered oxygen transport by hemoglobin. Basic therapy carried out with the use of antiaggregants, statins, antianginals, beta-blockers, and calcium antagonists does not help to recover the morphofunctional properties of erythrocytes. Based on the results the authors assume that, for the relief of the ischemic crisis and further therapeutic treatment, it is necessary to include, in addition to cardiovascular disease medicines, medication that increases the ability of erythrocytes' hemoglobin to transport oxygen to the tissues. We assume that the use of LIM and Raman spectroscopy is advisable for early diagnosis of changes in the structure and functional state of erythrocytes when cardiovascular diseases develop.",

author = "Revin, \{Victor V.\} and Gromova, \{Natalia V.\} and Revina, \{Elvira S.\} and Martynova, \{Maria I.\} and Seikina, \{Angelina I.\} and Revina, \{Nadezhda V.\} and Imarova, \{Oksana G.\} and Solomadin, \{Ilia N.\} and Tychkov, \{Alexander Yu\} and Nikolai Zhelev",

year = "2016",

doi = "10.1155/2016/3429604",

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T1 - Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases

AU - Revin, Victor V.

AU - Gromova, Natalia V.

AU - Revina, Elvira S.

AU - Martynova, Maria I.

AU - Seikina, Angelina I.

AU - Revina, Nadezhda V.

AU - Imarova, Oksana G.

AU - Solomadin, Ilia N.

AU - Tychkov, Alexander Yu

AU - Zhelev, Nikolai

PY - 2016

Y1 - 2016

N2 - The composition and condition of membrane lipids, the morphology of erythrocytes, and hemoglobin distribution were explored with the help of laser interference microscopy (LIM) and Raman spectroscopy. It is shown that patients with cardiovascular diseases (CVD) have significant changes in the composition of their phospholipids and the fatty acids of membrane lipids. Furthermore, the microviscosity of the membranes and morphology of the erythrocytes are altered causing disordered oxygen transport by hemoglobin. Basic therapy carried out with the use of antiaggregants, statins, antianginals, beta-blockers, and calcium antagonists does not help to recover the morphofunctional properties of erythrocytes. Based on the results the authors assume that, for the relief of the ischemic crisis and further therapeutic treatment, it is necessary to include, in addition to cardiovascular disease medicines, medication that increases the ability of erythrocytes' hemoglobin to transport oxygen to the tissues. We assume that the use of LIM and Raman spectroscopy is advisable for early diagnosis of changes in the structure and functional state of erythrocytes when cardiovascular diseases develop.

AB - The composition and condition of membrane lipids, the morphology of erythrocytes, and hemoglobin distribution were explored with the help of laser interference microscopy (LIM) and Raman spectroscopy. It is shown that patients with cardiovascular diseases (CVD) have significant changes in the composition of their phospholipids and the fatty acids of membrane lipids. Furthermore, the microviscosity of the membranes and morphology of the erythrocytes are altered causing disordered oxygen transport by hemoglobin. Basic therapy carried out with the use of antiaggregants, statins, antianginals, beta-blockers, and calcium antagonists does not help to recover the morphofunctional properties of erythrocytes. Based on the results the authors assume that, for the relief of the ischemic crisis and further therapeutic treatment, it is necessary to include, in addition to cardiovascular disease medicines, medication that increases the ability of erythrocytes' hemoglobin to transport oxygen to the tissues. We assume that the use of LIM and Raman spectroscopy is advisable for early diagnosis of changes in the structure and functional state of erythrocytes when cardiovascular diseases develop.

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DO - 10.1155/2016/3429604

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SN - 2314-6133

VL - 2016

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EP - 11

JO - BioMed Research International

JF - BioMed Research International

M1 - 3429604

ER -

Role of membrane lipids in the regulation of erythrocytic oxygen-transport function in cardiovascular diseases

Abstract

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