TY - JOUR
T1 - Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila
AU - Ruohola, H.
AU - Bremer, K. A.
AU - Baker, David
AU - Swedlow, J. R.
AU - Jan, L. Y.
AU - Jan, Y. N.
N1 - Funding Information:
We would like to thank Donald Ready for sending the p’ allele, Jose Campos-Ortega for the Dp(3;3) 02 stock, and Bernd Kramatschek for DlcDNA clone ~3.2. We are indebted to Gabrielle Boulianne for sharing unpublished data on neu alleles and neu cDNA clone and to Hugo Bellen for discussions. We thank Yi Rao for the bib cDNA clone, Wolfgang Driever and Christian Ntisslein-Volhard for the bed cDNA clone, Simon Kidd, Mike Young, and Susan Parmelee for the N clone, and especially Anne Ephrussi and Ruth Lehmann for osk cDNA prior to publication. Finally, we thank Ed Grell and Susan Shepherd for advice in genetics, Sandy Barbel and Bob Carretto for technical help, and Patrick O’Farrell, Bruce Hay, Ed Giniger, Vivian Siegel, Tom Jongens, and Harald Vaessin for constructive criticism on the manuscript. Also we would like to thank Kathi Prewitt for typing the manuscript and Larry Ackerman for illustrations. H. R. was supported by a Postdoctoral Fellowship from the European Molecular Biology Organization, and D. B. was supported by a Postdoctoral Fellowship from the Life Sciences Research Foundation. L. Y. J. and Y. N. J. are Investigators of the Howard Hughes Medical Institute.
PY - 1991/8/9
Y1 - 1991/8/9
N2 - Oogenesis in Drosophila involves specification of both germ cells and the surrounding somatic follicle cells, as well as the determination of oocyte polarity. We found that two neurogenic genes, Notch and Delta, are required in oogenesis. These genes encode membrane proteins with epidermal growth factor repeats and are essential in the decision of an embryonic ectodermal cell to take on the fate of neuroblast or epidermoblast. In oogenesis, mutation in either gene leads to an excess of posterior follicle cells, a cell fate change reminiscent of the hyperplasia of neuroblasts seen in neurogenic mutant embryos. Furthermore, the Notch mutation in somatic cells causes mislocalization of bicoid in the oocyte. These results suggest that the neurogenic genes Notch and Delta are involved in both follicle cell development and the establishment of anterior-posterior polarity in the oocyte.
AB - Oogenesis in Drosophila involves specification of both germ cells and the surrounding somatic follicle cells, as well as the determination of oocyte polarity. We found that two neurogenic genes, Notch and Delta, are required in oogenesis. These genes encode membrane proteins with epidermal growth factor repeats and are essential in the decision of an embryonic ectodermal cell to take on the fate of neuroblast or epidermoblast. In oogenesis, mutation in either gene leads to an excess of posterior follicle cells, a cell fate change reminiscent of the hyperplasia of neuroblasts seen in neurogenic mutant embryos. Furthermore, the Notch mutation in somatic cells causes mislocalization of bicoid in the oocyte. These results suggest that the neurogenic genes Notch and Delta are involved in both follicle cell development and the establishment of anterior-posterior polarity in the oocyte.
UR - http://www.scopus.com/inward/record.url?scp=0025986767&partnerID=8YFLogxK
U2 - 10.1016/0092-8674(81)90008-8
DO - 10.1016/0092-8674(81)90008-8
M3 - Article
C2 - 1907889
AN - SCOPUS:0025986767
SN - 0092-8674
VL - 66
SP - 433
EP - 449
JO - Cell
JF - Cell
IS - 3
ER -