Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress

Jacob George, Allan D. Struthers

    Research output: Contribution to journalArticle

    120 Citations (Scopus)
    2463 Downloads (Pure)

    Abstract

    Oxidative stress plays an important role in the progression of vascular endothelial dysfunction. The two major systems generating vascular oxidative stress are the NADPH oxidase and the xanthine oxidase pathways. Allopurinol, a xanthine oxidase inhibitor, has been in clinical use for over 40 years in the treatment of chronic gout. Allopurinol has also been shown to improve endothelial dysfunction, reduce oxidative stress burden and improve myocardial efficiency by reducing oxygen consumption in smaller mechanistic studies involving various cohorts at risk of cardiovascular events. This article aims to explain the role of xanthine oxidase in vascular oxidative stress and to explore the mechanisms by which allopurinol is thought to improve vascular and myocardial indices.
    Original languageEnglish
    Pages (from-to)265-272
    Number of pages8
    JournalVascular Health and Risk Management
    Volume5
    Issue number1
    DOIs
    Publication statusPublished - 2009

    Fingerprint Dive into the research topics of 'Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress'. Together they form a unique fingerprint.

  • Cite this