Roles for asparagine endopeptidase in class II MHC-restricted antigen processing

TY - JOUR

T1 - Roles for asparagine endopeptidase in class II MHC-restricted antigen processing

AU - Watts, Colin

AU - Mazzeo, Daniela

AU - West, Michelle A.

AU - Matthews, Stephen P.

AU - Keane, Doreen

AU - Hamilton, Garth

AU - Persson, Linda V.

AU - Lawson, Jennifer M.

AU - Manoury, Bénédicte

AU - Moss, Catherine X.

PY - 2003/9

Y1 - 2003/9

N2 - The adaptive immune response depends on the creation of suitable peptides from foreign antigens for display on MHC molecules to T lymphocytes. Similarly, MHC-restricted display of peptides derived from self proteins results in the elimination of many potentially autoreactive T cells. Different proteolytic systems are used to generate the peptides that are displayed as T cell epitopes on class I compared with class II MHC molecules. In the case of class II MHC molecules, the proteases that reside within the endosome/lysosome system of antigen-presenting cells are responsible; surprisingly, however, there are relatively few data on which enzymes are involved. Recently we have asked whether proteolysis is required simply in a generic sense, or whether the action of particular enzymes is needed to generate specific class II MHC-associated T cell epitopes. Using the recently identified mammalian asparagine endopeptidase as an example, we review recent evidence that individual enzymes can make clear and non-redundant contributions to MHC-restricted peptide display.

AB - The adaptive immune response depends on the creation of suitable peptides from foreign antigens for display on MHC molecules to T lymphocytes. Similarly, MHC-restricted display of peptides derived from self proteins results in the elimination of many potentially autoreactive T cells. Different proteolytic systems are used to generate the peptides that are displayed as T cell epitopes on class I compared with class II MHC molecules. In the case of class II MHC molecules, the proteases that reside within the endosome/lysosome system of antigen-presenting cells are responsible; surprisingly, however, there are relatively few data on which enzymes are involved. Recently we have asked whether proteolysis is required simply in a generic sense, or whether the action of particular enzymes is needed to generate specific class II MHC-associated T cell epitopes. Using the recently identified mammalian asparagine endopeptidase as an example, we review recent evidence that individual enzymes can make clear and non-redundant contributions to MHC-restricted peptide display.

UR - https://www.scopus.com/pages/publications/1542705057

U2 - 10.1042/bss0700031

DO - 10.1042/bss0700031

M3 - Article

C2 - 14587280

AN - SCOPUS:1542705057

SN - 0067-8694

VL - 70

SP - 31

EP - 38

JO - Biochemical Society Symposium

JF - Biochemical Society Symposium

ER -