Roles of glycans in protozoal host-parasite interactions

Giulia Bandini; Michael A.J. Ferguson

doi:10.1016/B978-0-12-821618-7.00018-3

Roles of glycans in protozoal host-parasite interactions

Giulia Bandini
, Michael A.J. Ferguson

Biological Chemistry and Drug Discovery

Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary

1 Citation (Scopus)

Abstract

Protozoan parasites are an extremely diverse group of organisms that affect human health worldwide. Glycans can play key roles in parasite virulence and they are often found at the center of the strategies these pathogens have evolved to interact with their hosts and transmission vectors. Here we describe some of the best characterized examples of glycan-mediated host-parasite interactions. The aim is to illustrate the spectrum of mechanisms and biomolecular structures employed by parasites to (1) recognize and attach to the host, (2) evade and modulate the immune response, and (3) build protective walls using glycans and glycan-binding proteins.

Original language	English
Title of host publication	Encyclopedia of Cell Biology
Editors	Ralph A. Bradshaw, Gerald W. Hart, Philip D. Stahl
Place of Publication	London
Publisher	Elsevier
Pages	363-372
Number of pages	10
Volume	4
Edition	2nd
ISBN (Electronic)	9780128216248
DOIs	https://doi.org/10.1016/B978-0-12-821618-7.00018-3
Publication status	Published - 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Glycan-binding proteins
Glycobiology
Glycoconjugates
Glycomimicry
Host-parasite interactions
Immune evasion
Lectins
Protists
Protozoan parasites
Scaffolding

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

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10.1016/B978-0-12-821618-7.00018-3Licence: Elsevier User Licence

Cite this

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title = "Roles of glycans in protozoal host-parasite interactions",

abstract = "Protozoan parasites are an extremely diverse group of organisms that affect human health worldwide. Glycans can play key roles in parasite virulence and they are often found at the center of the strategies these pathogens have evolved to interact with their hosts and transmission vectors. Here we describe some of the best characterized examples of glycan-mediated host-parasite interactions. The aim is to illustrate the spectrum of mechanisms and biomolecular structures employed by parasites to (1) recognize and attach to the host, (2) evade and modulate the immune response, and (3) build protective walls using glycans and glycan-binding proteins.",

keywords = "Glycan-binding proteins, Glycobiology, Glycoconjugates, Glycomimicry, Host-parasite interactions, Immune evasion, Lectins, Protists, Protozoan parasites, Scaffolding",

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T1 - Roles of glycans in protozoal host-parasite interactions

AU - Bandini, Giulia

AU - Ferguson, Michael A.J.

PY - 2023

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AB - Protozoan parasites are an extremely diverse group of organisms that affect human health worldwide. Glycans can play key roles in parasite virulence and they are often found at the center of the strategies these pathogens have evolved to interact with their hosts and transmission vectors. Here we describe some of the best characterized examples of glycan-mediated host-parasite interactions. The aim is to illustrate the spectrum of mechanisms and biomolecular structures employed by parasites to (1) recognize and attach to the host, (2) evade and modulate the immune response, and (3) build protective walls using glycans and glycan-binding proteins.

KW - Glycan-binding proteins

KW - Glycobiology

KW - Glycoconjugates

KW - Glycomimicry

KW - Host-parasite interactions

KW - Immune evasion

KW - Lectins

KW - Protists

KW - Protozoan parasites

KW - Scaffolding

UR - https://www.scopus.com/pages/publications/85158922536

U2 - 10.1016/B978-0-12-821618-7.00018-3

DO - 10.1016/B978-0-12-821618-7.00018-3

M3 - Entry for encyclopedia/dictionary

AN - SCOPUS:85158922536

VL - 4

SP - 363

EP - 372

BT - Encyclopedia of Cell Biology

A2 - Bradshaw, Ralph A.

A2 - Hart, Gerald W.

A2 - Stahl, Philip D.

PB - Elsevier

CY - London

ER -

Roles of glycans in protozoal host-parasite interactions

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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