Roles of HIF and 2-Oxoglutarate-Dependent Dioxygenases in Controlling Gene Expression in Hypoxia

Julianty Frost, Mark Frost, Michael Batie, Hao Jiang, Sonia Rocha (Lead / Corresponding author)

    Research output: Contribution to journalReview articlepeer-review

    20 Citations (Scopus)
    91 Downloads (Pure)

    Abstract

    Hypoxia-reduction in oxygen availability-plays key roles in both physiological and pathological processes. Given the importance of oxygen for cell and organism viability, mechanisms to sense and respond to hypoxia are in place. A variety of enzymes utilise molecular oxygen, but of particular importance to oxygen sensing are the 2-oxoglutarate (2-OG) dependent dioxygenases (2-OGDs). Of these, Prolyl-hydroxylases have long been recognised to control the levels and function of Hypoxia Inducible Factor (HIF), a master transcriptional regulator in hypoxia, via their hydroxylase activity. However, recent studies are revealing that dioxygenases are involved in almost all aspects of gene regulation, including chromatin organisation, transcription and translation. We highlight the relevance of HIF and 2-OGDs in the control of gene expression in response to hypoxia and their relevance to human biology and health.

    Original languageEnglish
    Article number350
    Number of pages31
    JournalCancers
    Volume13
    Issue number2
    DOIs
    Publication statusPublished - 19 Jan 2021

    Keywords

    • hypoxia
    • 2-OG dioxygenases
    • chromatin
    • transcription
    • translation
    • cancer
    • Chromatin
    • Translation
    • Transcription
    • Hypoxia
    • Cancer

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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