Routes to and from the plasma membrane: Bulk flow versus signal mediated endocytosis

David C. Gershlick, Carine De Marcos Lousa, Lucy Farmer, Jurgen Denecke (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Transport of proteins via the secretory pathway is controlled by a combination of signal dependent cargo selection as well as unspecific bulk flow of membranes and aqueous lumen. Using the plant vacuolar sorting receptor as model for membrane spanning proteins, we have distinguished bulk flow from signal mediated protein targeting in biosynthetic and endocytic transport routes and investigated the influence of transmembrane domain length. More specifically, long transmembrane domains seem to prevent ER retention, either by stimulating export or preventing recycling from post ER compartments. Long transmembrane domains also seem to prevent endocytic bulk flow from the plasma membrane, but the presence of specific endocytosis signals overrules this in a dominant manner.

Original languageEnglish
Article numbere972813
Number of pages3
JournalPlant Signaling and Behavior
Issue number10
Early online date31 Oct 2014
Publication statusPublished - 22 Dec 2014


  • Bulk-flow
  • Endocytosis
  • Protein trafficking
  • Sorting motifs
  • Vacuolar sorting receptor

ASJC Scopus subject areas

  • Plant Science


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