Routine assessment of nutritional, functional and inflammatory criteria in patients with cancer: A systematic review

TY - JOUR

T1 - Routine assessment of nutritional, functional and inflammatory criteria in patients with cancer

T2 - A systematic review

AU - Pumtako, Chattarin

AU - Dolan, Ross D

AU - McGovern, Josh

AU - McMillan, Donald C

N1 - Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.

PY - 2024/10

Y1 - 2024/10

N2 - BACKGROUND: The review discusses the significant impact of cancer on patients, particularly focusing on cachexia - a condition marked by weight and lean tissue loss. This condition critically affects the nutritional status, quality of life, and treatment outcomes of cancer patients.RESEARCH QUESTION: The review seeks to understand the effectiveness and necessity of routine clinical monitoring of cancer cachexia, and how it can aid in better therapeutic interventions.METHODS: The systematic review followed a pre-defined protocol based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)statement. A systematic search using specific keywords was conducted in PubMed and EMBASE databases on October 24, 2023, supplemented by citations from the original papers. The selection process involved screening titles and abstracts for relevance.RESULTS: The review finds varying levels of effectiveness in the different measurement criteria used for monitoring cachexia. It highlights the potential of the Global Leadership Initiative on Malnutrition (GLIM) framework in defining and managing cancer cachexia, though noting some challenges in standardisation and implementation of measurements.CONCLUSION: The present systematic review highlights the variability and lack of standardization in the application of GLIM criteria for monitoring cachexia in cancer patients. Despite these challenges, it will be important to determine the most efficacious clinically routine nutritional and inflammation assessments in the routine application of GLIM criteria assessment.

AB - BACKGROUND: The review discusses the significant impact of cancer on patients, particularly focusing on cachexia - a condition marked by weight and lean tissue loss. This condition critically affects the nutritional status, quality of life, and treatment outcomes of cancer patients.RESEARCH QUESTION: The review seeks to understand the effectiveness and necessity of routine clinical monitoring of cancer cachexia, and how it can aid in better therapeutic interventions.METHODS: The systematic review followed a pre-defined protocol based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)statement. A systematic search using specific keywords was conducted in PubMed and EMBASE databases on October 24, 2023, supplemented by citations from the original papers. The selection process involved screening titles and abstracts for relevance.RESULTS: The review finds varying levels of effectiveness in the different measurement criteria used for monitoring cachexia. It highlights the potential of the Global Leadership Initiative on Malnutrition (GLIM) framework in defining and managing cancer cachexia, though noting some challenges in standardisation and implementation of measurements.CONCLUSION: The present systematic review highlights the variability and lack of standardization in the application of GLIM criteria for monitoring cachexia in cancer patients. Despite these challenges, it will be important to determine the most efficacious clinically routine nutritional and inflammation assessments in the routine application of GLIM criteria assessment.

KW - Humans

KW - Cachexia/therapy

KW - Inflammation

KW - Malnutrition

KW - Neoplasms/complications

KW - Nutrition Assessment

KW - Nutritional Status

KW - Quality of Life

U2 - 10.1016/j.clnesp.2024.06.052

DO - 10.1016/j.clnesp.2024.06.052

M3 - Article

C2 - 38980797

SN - 2405-4577

VL - 63

SP - 294

EP - 303

JO - Clinical Nutrition ESPEN

JF - Clinical Nutrition ESPEN

ER -