Abstract
In all eukaryotes, entry into mitosis from G2 phase is initiated by a complex of the cdc2 kinase and a B-type cyclin. It has now been shown that, in fission yeast, B-type cyclins also activate cdc2 in G1, thus governing cell-cycle commitment, as well as the onset of S phase. In this article, Karim Labib and Sergio Moreno review the evidence that rum1 inhibits the kinase activity of cdc2 associated with B-type cyclins and is an important regulator of G1 progression in fission yeast.
| Original language | English |
|---|---|
| Pages (from-to) | 62-66 |
| Number of pages | 5 |
| Journal | Trends in Cell Biology |
| Volume | 6 |
| Issue number | 2 |
| Publication status | Published - Feb 1996 |
Keywords
- DIVISION
- CELL-CYCLE GENE
- CDC13
- CLONING
- MITOSIS
- PROTEIN-KINASE