rum1: A CDK inhibitor regulating G1 progression in fission yeast

K Labib, S Moreno

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    21 Citations (Scopus)

    Abstract

    In all eukaryotes, entry into mitosis from G2 phase is initiated by a complex of the cdc2 kinase and a B-type cyclin. It has now been shown that, in fission yeast, B-type cyclins also activate cdc2 in G1, thus governing cell-cycle commitment, as well as the onset of S phase. In this article, Karim Labib and Sergio Moreno review the evidence that rum1 inhibits the kinase activity of cdc2 associated with B-type cyclins and is an important regulator of G1 progression in fission yeast.

    Original languageEnglish
    Pages (from-to)62-66
    Number of pages5
    JournalTrends in Cell Biology
    Volume6
    Issue number2
    Publication statusPublished - Feb 1996

    Keywords

    • DIVISION
    • CELL-CYCLE GENE
    • CDC13
    • CLONING
    • MITOSIS
    • PROTEIN-KINASE

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