rum1: A CDK inhibitor regulating G1 progression in fission yeast

K Labib; S Moreno

rum1: A CDK inhibitor regulating G1 progression in fission yeast

K Labib
, S Moreno

Research output: Contribution to journal › Article › peer-review

Abstract

In all eukaryotes, entry into mitosis from G2 phase is initiated by a complex of the cdc2 kinase and a B-type cyclin. It has now been shown that, in fission yeast, B-type cyclins also activate cdc2 in G1, thus governing cell-cycle commitment, as well as the onset of S phase. In this article, Karim Labib and Sergio Moreno review the evidence that rum1 inhibits the kinase activity of cdc2 associated with B-type cyclins and is an important regulator of G1 progression in fission yeast.

Original language	English
Pages (from-to)	62-66
Number of pages	5
Journal	Trends in Cell Biology
Volume	6
Issue number	2
Publication status	Published - Feb 1996

Keywords

DIVISION
CELL-CYCLE GENE
CDC13
CLONING
MITOSIS
PROTEIN-KINASE

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Cite this

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title = "rum1: A CDK inhibitor regulating G1 progression in fission yeast",

abstract = "In all eukaryotes, entry into mitosis from G2 phase is initiated by a complex of the cdc2 kinase and a B-type cyclin. It has now been shown that, in fission yeast, B-type cyclins also activate cdc2 in G1, thus governing cell-cycle commitment, as well as the onset of S phase. In this article, Karim Labib and Sergio Moreno review the evidence that rum1 inhibits the kinase activity of cdc2 associated with B-type cyclins and is an important regulator of G1 progression in fission yeast.",

keywords = "DIVISION, CELL-CYCLE GENE, CDC13, CLONING, MITOSIS, PROTEIN-KINASE",

author = "K Labib and S Moreno",

year = "1996",

month = feb,

language = "English",

volume = "6",

pages = "62--66",

journal = "Trends in Cell Biology",

issn = "0962-8924",

publisher = "Elsevier",

number = "2",

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TY - JOUR

T1 - rum1

T2 - A CDK inhibitor regulating G1 progression in fission yeast

AU - Labib, K

AU - Moreno, S

PY - 1996/2

Y1 - 1996/2

N2 - In all eukaryotes, entry into mitosis from G2 phase is initiated by a complex of the cdc2 kinase and a B-type cyclin. It has now been shown that, in fission yeast, B-type cyclins also activate cdc2 in G1, thus governing cell-cycle commitment, as well as the onset of S phase. In this article, Karim Labib and Sergio Moreno review the evidence that rum1 inhibits the kinase activity of cdc2 associated with B-type cyclins and is an important regulator of G1 progression in fission yeast.

AB - In all eukaryotes, entry into mitosis from G2 phase is initiated by a complex of the cdc2 kinase and a B-type cyclin. It has now been shown that, in fission yeast, B-type cyclins also activate cdc2 in G1, thus governing cell-cycle commitment, as well as the onset of S phase. In this article, Karim Labib and Sergio Moreno review the evidence that rum1 inhibits the kinase activity of cdc2 associated with B-type cyclins and is an important regulator of G1 progression in fission yeast.

KW - DIVISION

KW - CELL-CYCLE GENE

KW - CDC13

KW - CLONING

KW - MITOSIS

KW - PROTEIN-KINASE

M3 - Article

SN - 0962-8924

VL - 6

SP - 62

EP - 66

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 2

ER -

rum1: A CDK inhibitor regulating G1 progression in fission yeast

Abstract

Keywords

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