S-palmitoylation and the regulation of NCX1

William Fuller (Lead / Corresponding author), Louise Reilly, Donald W. Hilgemann

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Investigations into reversible cysteine acylation (S-palmitoylation) have enjoyed a renaissance recently, thanks to numerous techniques that have improved the sensitivity of detection above the traditional use of 3H-palmitate. Often considered a largely static modifi-cation necessary only for traffic of membrane proteins through the secretory pathway, an appreciation is now growing that S-almitoylation dynamically regulates the landscape of the cell surface in unexpected ways, including the formation and endocytosis of protein/lipid domains, as well as directly modulating ion channel and transporter function.
Original languageEnglish
Pages (from-to)75-77
Number of pages3
JournalChannels
Volume10
Issue number2
Early online date29 Sep 2015
DOIs
Publication statusPublished - 3 Mar 2016

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