S-palmitoylation and the regulation of NCX1

TY - JOUR

T1 - S-palmitoylation and the regulation of NCX1

AU - Fuller, William

AU - Reilly, Louise

AU - Hilgemann, Donald W.

PY - 2016/3/3

Y1 - 2016/3/3

N2 - Investigations into reversible cysteine acylation (S-palmitoylation) have enjoyed a renaissance recently, thanks to numerous techniques that have improved the sensitivity of detection above the traditional use of 3H-palmitate. Often considered a largely static modifi-cation necessary only for traffic of membrane proteins through the secretory pathway, an appreciation is now growing that S-almitoylation dynamically regulates the landscape of the cell surface in unexpected ways, including the formation and endocytosis of protein/lipid domains, as well as directly modulating ion channel and transporter function.

AB - Investigations into reversible cysteine acylation (S-palmitoylation) have enjoyed a renaissance recently, thanks to numerous techniques that have improved the sensitivity of detection above the traditional use of 3H-palmitate. Often considered a largely static modifi-cation necessary only for traffic of membrane proteins through the secretory pathway, an appreciation is now growing that S-almitoylation dynamically regulates the landscape of the cell surface in unexpected ways, including the formation and endocytosis of protein/lipid domains, as well as directly modulating ion channel and transporter function.

U2 - 10.1080/19336950.2015.1099329

DO - 10.1080/19336950.2015.1099329

M3 - Article

C2 - 26418268

SN - 1933-6950

VL - 10

SP - 75

EP - 77

JO - Channels

JF - Channels

IS - 2

ER -