Sacubitril and valsartan fixed combination to reduce heart failure events in post-acute myocardial infarction patients

M. Zaid Iskandar, C. C. Lang

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    16 Citations (Scopus)
    641 Downloads (Pure)

    Abstract

    Heart failure is a term used to define a constellation of symptoms and signs that are commonly attributed to the inability of the heart to produce a cardiac output that meets the demands of the body. It remains a deadly disease, affecting between 1-2% of the population, and is more common in the elderly, with around 6-10% of patients over 65 suffering from the condition. Sacubitril/valsartan (LCZ-696) is a combined neprilysin inhibitor and angiotensin AT1 receptor blocker approved in recent years for the treatment of chronic heart failure with reduced ejection fraction. In an area where there have been limited pharmacological advances in the last 10 years, this drug was a game changer and a much welcomed addition to contemporary heart failure therapy. It is currently being studied in patients with heart failure with preserved ejection fraction and for the reduction of heart failure events post-acute myocardial infarction. Results from the ongoing PARADISE-MI study are awaited by the global cardiology community with great interest.

    Original languageEnglish
    Pages (from-to)545-551
    Number of pages7
    JournalDrugs of Today
    Volume53
    Issue number10
    DOIs
    Publication statusPublished - Oct 2017

    Keywords

    • Sacubitril/valsartan
    • LCZ-696
    • Heart failure
    • Myocardial infarction

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