Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors

meta-analysis of controlled clinical trials

Daniel R. Morales (Lead / Corresponding author), Brian J. Lipworth, Bruce Guthrie, Cathy Jackson, Peter T. Donnan, Virginia H. Santiago

    Research output: Contribution to journalArticle

    37 Citations (Scopus)

    Abstract

    Nonsteroidal anti-inflammatory drugs (NSAIDs) cause bronchospasm in susceptible patients with asthma, often termed aspirin-exacerbated respiratory disease (AERD), with the risk being greatest after acute exposure. Selective NSAIDs that preferentially inhibit COX-2 might be safer.
    Original languageEnglish
    Pages (from-to)40-45.e10
    Number of pages16
    JournalJournal of Allergy and Clinical Immunology
    Volume134
    Issue number1
    Early online date31 Dec 2013
    DOIs
    Publication statusPublished - Jul 2014

    Fingerprint

    Cyclooxygenase 2 Inhibitors
    Controlled Clinical Trials
    Acute Disease
    Patient Safety
    Aspirin
    Meta-Analysis
    Anti-Inflammatory Agents
    Bronchial Spasm
    Pharmaceutical Preparations
    Asthma

    Keywords

    • Asthma
    • aspirin-exacerbated respiratory disease
    • aspirin-induced asthma
    • aspirin-sensitive asthma
    • nonsteriodal anti-inflammatory agents
    • COX-2 inhibitors
    • Systematic review
    • Meta-analysis
    • PHARMACOEPIDEMIOLOGY

    Cite this

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    title = "Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: meta-analysis of controlled clinical trials",
    abstract = "Nonsteroidal anti-inflammatory drugs (NSAIDs) cause bronchospasm in susceptible patients with asthma, often termed aspirin-exacerbated respiratory disease (AERD), with the risk being greatest after acute exposure. Selective NSAIDs that preferentially inhibit COX-2 might be safer.",
    keywords = "Asthma, aspirin-exacerbated respiratory disease, aspirin-induced asthma, aspirin-sensitive asthma, nonsteriodal anti-inflammatory agents, COX-2 inhibitors, Systematic review, Meta-analysis, PHARMACOEPIDEMIOLOGY",
    author = "Morales, {Daniel R.} and Lipworth, {Brian J.} and Bruce Guthrie and Cathy Jackson and Donnan, {Peter T.} and Santiago, {Virginia H.}",
    note = "Copyright {\circledC} 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.",
    year = "2014",
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    T2 - meta-analysis of controlled clinical trials

    AU - Morales, Daniel R.

    AU - Lipworth, Brian J.

    AU - Guthrie, Bruce

    AU - Jackson, Cathy

    AU - Donnan, Peter T.

    AU - Santiago, Virginia H.

    N1 - Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

    PY - 2014/7

    Y1 - 2014/7

    N2 - Nonsteroidal anti-inflammatory drugs (NSAIDs) cause bronchospasm in susceptible patients with asthma, often termed aspirin-exacerbated respiratory disease (AERD), with the risk being greatest after acute exposure. Selective NSAIDs that preferentially inhibit COX-2 might be safer.

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    KW - aspirin-exacerbated respiratory disease

    KW - aspirin-induced asthma

    KW - aspirin-sensitive asthma

    KW - nonsteriodal anti-inflammatory agents

    KW - COX-2 inhibitors

    KW - Systematic review

    KW - Meta-analysis

    KW - PHARMACOEPIDEMIOLOGY

    U2 - 10.1016/j.jaci.2013.10.057

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