Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: meta-analysis of controlled clinical trials

Daniel R. Morales; Brian J. Lipworth; Bruce Guthrie; Cathy Jackson; Peter T. Donnan; Virginia H.  Santiago

doi:10.1016/j.jaci.2013.10.057

Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: meta-analysis of controlled clinical trials

Daniel R. Morales (Lead / Corresponding author), Brian J. Lipworth, Bruce Guthrie, Cathy Jackson, Peter T. Donnan, Virginia H. Santiago

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) cause bronchospasm in susceptible patients with asthma, often termed aspirin-exacerbated respiratory disease (AERD), with the risk being greatest after acute exposure. Selective NSAIDs that preferentially inhibit COX-2 might be safer.

Original language	English
Pages (from-to)	40-45.e10
Number of pages	16
Journal	Journal of Allergy and Clinical Immunology
Volume	134
Issue number	1
Early online date	31 Dec 2013
DOIs	https://doi.org/10.1016/j.jaci.2013.10.057
Publication status	Published - Jul 2014

Keywords

Asthma
aspirin-exacerbated respiratory disease
aspirin-induced asthma
aspirin-sensitive asthma
nonsteriodal anti-inflammatory agents
COX-2 inhibitors
Systematic review
Meta-analysis
PHARMACOEPIDEMIOLOGY

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http://www.sciencedirect.com/science/journal/00916749

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A Multilevel Analysis of the Impact of Changes in Antimicrobial Prescribing on Antibiotic Resistance (Scottish Clinical Academic Training Fellowship)
Davey, P. (Investigator), Guthrie, B. (Investigator), Hernandez Santiago, V. (Investigator) & Marwick, C. (Investigator)
1/04/13 → 31/10/17
Project: Research

Lipworth, Brian
- Respiratory Medicine and Gastroenterology - Clinical Professor (Teaching and Research) of Allergy and Respiratory Medicine
Person: Academic
Morales, Daniel
- Population Health and Genomics - Wellcome Trust Clinical Research Fellow
Person: Research

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Morales, D. R., Lipworth, B. J., Guthrie, B., Jackson, C., Donnan, P. T., & Santiago, V. H. (2014). Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: meta-analysis of controlled clinical trials. Journal of Allergy and Clinical Immunology, 134(1), 40-45.e10. https://doi.org/10.1016/j.jaci.2013.10.057

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title = "Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: meta-analysis of controlled clinical trials",

abstract = "Nonsteroidal anti-inflammatory drugs (NSAIDs) cause bronchospasm in susceptible patients with asthma, often termed aspirin-exacerbated respiratory disease (AERD), with the risk being greatest after acute exposure. Selective NSAIDs that preferentially inhibit COX-2 might be safer.",

keywords = "Asthma, aspirin-exacerbated respiratory disease, aspirin-induced asthma, aspirin-sensitive asthma, nonsteriodal anti-inflammatory agents, COX-2 inhibitors, Systematic review, Meta-analysis, PHARMACOEPIDEMIOLOGY",

author = "Morales, {Daniel R.} and Lipworth, {Brian J.} and Bruce Guthrie and Cathy Jackson and Donnan, {Peter T.} and Santiago, {Virginia H.}",

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Morales, DR , Lipworth, BJ, Guthrie, B, Jackson, C, Donnan, PT & Santiago, VH 2014, 'Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: meta-analysis of controlled clinical trials', Journal of Allergy and Clinical Immunology, vol. 134, no. 1, pp. 40-45.e10. https://doi.org/10.1016/j.jaci.2013.10.057

Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: meta-analysis of controlled clinical trials. / Morales, Daniel R. (Lead / Corresponding author); Lipworth, Brian J.; Guthrie, Bruce et al.
In: Journal of Allergy and Clinical Immunology, Vol. 134, No. 1, 07.2014, p. 40-45.e10.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors

T2 - meta-analysis of controlled clinical trials

AU - Morales, Daniel R.

AU - Lipworth, Brian J.

AU - Guthrie, Bruce

AU - Jackson, Cathy

AU - Donnan, Peter T.

AU - Santiago, Virginia H.

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AB - Nonsteroidal anti-inflammatory drugs (NSAIDs) cause bronchospasm in susceptible patients with asthma, often termed aspirin-exacerbated respiratory disease (AERD), with the risk being greatest after acute exposure. Selective NSAIDs that preferentially inhibit COX-2 might be safer.

KW - Asthma

KW - aspirin-exacerbated respiratory disease

KW - aspirin-induced asthma

KW - aspirin-sensitive asthma

KW - nonsteriodal anti-inflammatory agents

KW - COX-2 inhibitors

KW - Systematic review

KW - Meta-analysis

KW - PHARMACOEPIDEMIOLOGY

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DO - 10.1016/j.jaci.2013.10.057

M3 - Article

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SN - 0091-6749

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SP - 40-45.e10

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 1

ER -

Morales DR , Lipworth BJ, Guthrie B, Jackson C, Donnan PT, Santiago VH. Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: meta-analysis of controlled clinical trials. Journal of Allergy and Clinical Immunology. 2014 Jul;134(1):40-45.e10. Epub 2013 Dec 31. doi: 10.1016/j.jaci.2013.10.057

Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: meta-analysis of controlled clinical trials

Abstract

Keywords

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Projects

A Multilevel Analysis of the Impact of Changes in Antimicrobial Prescribing on Antibiotic Resistance (Scottish Clinical Academic Training Fellowship)

Profiles

Lipworth, Brian

Morales, Daniel

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