SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56

Pedro Barbosa, Liudmila Zhaunova, Simona Debilio, Verdiana Steccanella, Van Kelly, Tony Ly, Hiroyuki Ohkura (Lead / Corresponding author)

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Meiosis creates genetic diversity by recombination and segregation of chromosomes. The synaptonemal complex assembles during meiotic prophase I and assists faithful exchanges between homologous chromosomes, but how its assembly/disassembly is regulated remains to be understood. Here, we report how two major posttranslational modifications, phosphorylation and ubiquitination, cooperate to promote synaptonemal complex assembly. We found that the ubiquitin ligase complex SCF is important for assembly and maintenance of the synaptonemal complex in Drosophila female meiosis. This function of SCF is mediated by two substrate-recognizing F-box proteins, Slmb/βTrcp and Fbxo42. SCF-Fbxo42 downregulates the phosphatase subunit PP2A-B56, which is important for synaptonemal complex assembly and maintenance.
Original languageEnglish
Article numbere202009167
Number of pages12
JournalJournal of Cell Biology
Issue number2
Publication statusPublished - 31 Dec 2020


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