SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner

Keyphrases

• Transcription Factor 100%
• Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 100%
• Glycogen Synthase kinase-3β (GSK-3β) 100%
• Kelch-like ECH-associated Protein 1 (Keap1) 100%
• Dependent Degradation 100%
• β-TrCP 100%
• Ubiquitination 11%
• Phosphorylation 5%
• Transcriptional Regulation 5%
• Null Mice 5%
• Glycogen Synthase kinase-3 Inhibitors 5%
• E3 Ubiquitin Ligase 5%
• Proteasomal Degradation 5%
• Redox-sensitive 5%
• Mouse Embryonic Fibroblasts 5%
• CUL3 5%
• Long Half-life 5%
• Dual Degradation 5%
• Degradation Model 5%

Biochemistry, Genetics and Molecular Biology

• Glycogen Synthase Kinase 3 100%
• Transcription Factor Nrf2 100%
• Ubiquitination 11%
• Knockout Mouse 5%
• Ubiquitin-Conjugating Enzyme 5%
• Fibroblast 5%
• phosphorylation 5%
• Half-Life 5%