Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

J.-C. Bourdon, J. Renzing, P. L. Robertson, K. N. Fernandes, D. P. Lane

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    p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we compared, by differential display, the expression of genes in spleen or thymus of normal and p53 nullizygote mice after gamma-irradiation of whole animals. We report the identification and characterization of human and mouse Scotin homologues, a novel gene directly transactivated by p53. The Scotin protein is localized to the ER and the nuclear membrane. Scotin can induce apoptosis in a caspase-dependent manner. Inhibition of endogenous Scotin expression increases resistance to p53-dependent apoptosis induced by DNA damage, suggesting that Scotin plays a role in p53-dependent apoptosis. The discovery of Scotin brings to light a role of the ER in p53-dependent apoptosis.

    © 2002 Bourdon et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at

    Original languageEnglish
    Pages (from-to)235-246
    Number of pages12
    JournalJournal of Cell Biology
    Issue number2
    Publication statusPublished - 22 Jul 2002


    • Transactivation
    • p53-binding site
    • Cell death
    • Cancer
    • 3p21


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