Seasonal variation in plasma levels of endothelin-1 and nitric oxide

M. McLaren, G. Kirk, C. Bolton-Smith, J. J. F. Belch

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    Background. There is a sea­son­al vari­a­tion in the inci­dence of ­stroke and cor­o­nary heart dis­ease with admis­sions to hos­pi­tal being high­er in the cold­er ­months of the year. The mech­a­nism where­by this win­ter prev­a­lence of vas­cu­lar dis­ease ­occurs is still not fully under­stood. The aim of our study was to meas­ure plas­ma lev­els of vasoac­tive com­pounds through­out the year to estab­lish wheth­er or not there were any fluc­tu­a­tions which could play a part in the high­er win­ter inci­dence.
    Methods. We meas­ured plas­ma lev­els of the vas­o­con­stric­tive endo­the­lin-1(ET) and the vasor­e­lax­ant ­nitric oxide (NO) through­out the year. Blood sam­ples were col­lect­ed from 176 nor­mal indi­vid­u­als. Samples were col­lect­ed ­between 8.00 and 10.00 hours after an over­night fast of at least 12 hours.
    Results. Results were divid­ed into two-month­ly inter­vals and ana­lysed using a Kruskal-Wallis one-way anal­y­sis of var­i­ance and Mann-Whitney U tests (SPSS). We found a sig­nif­i­cant sea­son­al vari­a­tion in both param­e­ters. Mean lev­els of endo­the­lin were high­est in January/February (4.0 pg/ml) and low­est in May/June (2.3 pg/ml), where­as plas­ma 5 ­nitric oxide lev­els were low­est in January/February (5.7 µM) and high­est in Septem-ber/October (9.9 µM); p val­ues were <0.0001 (Jan/Feb vs May/June) and 0.049 (Jan/Feb vs Sept/Oct), respec­tive­ly.
    Conclusions. The high lev­els of the vas­o­con­stric­tor endo­the­lin com­bined with low lev­els of vasor­e­lax­ant ­nitric oxide may ­account in part for the ­increased inci­dence of ­stroke and cor­o­nary heart dis­ease seen in these ­months.
    Original languageEnglish
    Pages (from-to)351-353
    Number of pages3
    JournalInternational Angiology
    Volume19
    Issue number4
    Publication statusPublished - Dec 2000

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    Endothelin-1
    Nitric Oxide
    Endothelins
    Vasodilator Agents
    Coronary Disease
    Incidence
    Stroke
    Vasoconstrictor Agents
    Nonparametric Statistics
    Vascular Diseases
    Analysis of Variance

    Cite this

    McLaren, M. ; Kirk, G. ; Bolton-Smith, C. ; Belch, J. J. F. / Seasonal variation in plasma levels of endothelin-1 and nitric oxide. In: International Angiology. 2000 ; Vol. 19, No. 4. pp. 351-353.
    @article{5f3395e5e1f949ceb9c267817833c622,
    title = "Seasonal variation in plasma levels of endothelin-1 and nitric oxide",
    abstract = "Background. There is a sea­son­al vari­a­tion in the inci­dence of ­stroke and cor­o­nary heart dis­ease with admis­sions to hos­pi­tal being high­er in the cold­er ­months of the year. The mech­a­nism where­by this win­ter prev­a­lence of vas­cu­lar dis­ease ­occurs is still not fully under­stood. The aim of our study was to meas­ure plas­ma lev­els of vasoac­tive com­pounds through­out the year to estab­lish wheth­er or not there were any fluc­tu­a­tions which could play a part in the high­er win­ter inci­dence.Methods. We meas­ured plas­ma lev­els of the vas­o­con­stric­tive endo­the­lin-1(ET) and the vasor­e­lax­ant ­nitric oxide (NO) through­out the year. Blood sam­ples were col­lect­ed from 176 nor­mal indi­vid­u­als. Samples were col­lect­ed ­between 8.00 and 10.00 hours after an over­night fast of at least 12 hours.Results. Results were divid­ed into two-month­ly inter­vals and ana­lysed using a Kruskal-Wallis one-way anal­y­sis of var­i­ance and Mann-Whitney U tests (SPSS). We found a sig­nif­i­cant sea­son­al vari­a­tion in both param­e­ters. Mean lev­els of endo­the­lin were high­est in January/February (4.0 pg/ml) and low­est in May/June (2.3 pg/ml), where­as plas­ma 5 ­nitric oxide lev­els were low­est in January/February (5.7 µM) and high­est in Septem-ber/October (9.9 µM); p val­ues were <0.0001 (Jan/Feb vs May/June) and 0.049 (Jan/Feb vs Sept/Oct), respec­tive­ly.Conclusions. The high lev­els of the vas­o­con­stric­tor endo­the­lin com­bined with low lev­els of vasor­e­lax­ant ­nitric oxide may ­account in part for the ­increased inci­dence of ­stroke and cor­o­nary heart dis­ease seen in these ­months.",
    author = "M. McLaren and G. Kirk and C. Bolton-Smith and Belch, {J. J. F.}",
    year = "2000",
    month = "12",
    language = "English",
    volume = "19",
    pages = "351--353",
    journal = "International Angiology",
    issn = "0392-9590",
    publisher = "SAGE Publications",
    number = "4",

    }

    McLaren, M, Kirk, G, Bolton-Smith, C & Belch, JJF 2000, 'Seasonal variation in plasma levels of endothelin-1 and nitric oxide', International Angiology, vol. 19, no. 4, pp. 351-353.

    Seasonal variation in plasma levels of endothelin-1 and nitric oxide. / McLaren, M.; Kirk, G.; Bolton-Smith, C.; Belch, J. J. F.

    In: International Angiology, Vol. 19, No. 4, 12.2000, p. 351-353.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Seasonal variation in plasma levels of endothelin-1 and nitric oxide

    AU - McLaren, M.

    AU - Kirk, G.

    AU - Bolton-Smith, C.

    AU - Belch, J. J. F.

    PY - 2000/12

    Y1 - 2000/12

    N2 - Background. There is a sea­son­al vari­a­tion in the inci­dence of ­stroke and cor­o­nary heart dis­ease with admis­sions to hos­pi­tal being high­er in the cold­er ­months of the year. The mech­a­nism where­by this win­ter prev­a­lence of vas­cu­lar dis­ease ­occurs is still not fully under­stood. The aim of our study was to meas­ure plas­ma lev­els of vasoac­tive com­pounds through­out the year to estab­lish wheth­er or not there were any fluc­tu­a­tions which could play a part in the high­er win­ter inci­dence.Methods. We meas­ured plas­ma lev­els of the vas­o­con­stric­tive endo­the­lin-1(ET) and the vasor­e­lax­ant ­nitric oxide (NO) through­out the year. Blood sam­ples were col­lect­ed from 176 nor­mal indi­vid­u­als. Samples were col­lect­ed ­between 8.00 and 10.00 hours after an over­night fast of at least 12 hours.Results. Results were divid­ed into two-month­ly inter­vals and ana­lysed using a Kruskal-Wallis one-way anal­y­sis of var­i­ance and Mann-Whitney U tests (SPSS). We found a sig­nif­i­cant sea­son­al vari­a­tion in both param­e­ters. Mean lev­els of endo­the­lin were high­est in January/February (4.0 pg/ml) and low­est in May/June (2.3 pg/ml), where­as plas­ma 5 ­nitric oxide lev­els were low­est in January/February (5.7 µM) and high­est in Septem-ber/October (9.9 µM); p val­ues were <0.0001 (Jan/Feb vs May/June) and 0.049 (Jan/Feb vs Sept/Oct), respec­tive­ly.Conclusions. The high lev­els of the vas­o­con­stric­tor endo­the­lin com­bined with low lev­els of vasor­e­lax­ant ­nitric oxide may ­account in part for the ­increased inci­dence of ­stroke and cor­o­nary heart dis­ease seen in these ­months.

    AB - Background. There is a sea­son­al vari­a­tion in the inci­dence of ­stroke and cor­o­nary heart dis­ease with admis­sions to hos­pi­tal being high­er in the cold­er ­months of the year. The mech­a­nism where­by this win­ter prev­a­lence of vas­cu­lar dis­ease ­occurs is still not fully under­stood. The aim of our study was to meas­ure plas­ma lev­els of vasoac­tive com­pounds through­out the year to estab­lish wheth­er or not there were any fluc­tu­a­tions which could play a part in the high­er win­ter inci­dence.Methods. We meas­ured plas­ma lev­els of the vas­o­con­stric­tive endo­the­lin-1(ET) and the vasor­e­lax­ant ­nitric oxide (NO) through­out the year. Blood sam­ples were col­lect­ed from 176 nor­mal indi­vid­u­als. Samples were col­lect­ed ­between 8.00 and 10.00 hours after an over­night fast of at least 12 hours.Results. Results were divid­ed into two-month­ly inter­vals and ana­lysed using a Kruskal-Wallis one-way anal­y­sis of var­i­ance and Mann-Whitney U tests (SPSS). We found a sig­nif­i­cant sea­son­al vari­a­tion in both param­e­ters. Mean lev­els of endo­the­lin were high­est in January/February (4.0 pg/ml) and low­est in May/June (2.3 pg/ml), where­as plas­ma 5 ­nitric oxide lev­els were low­est in January/February (5.7 µM) and high­est in Septem-ber/October (9.9 µM); p val­ues were <0.0001 (Jan/Feb vs May/June) and 0.049 (Jan/Feb vs Sept/Oct), respec­tive­ly.Conclusions. The high lev­els of the vas­o­con­stric­tor endo­the­lin com­bined with low lev­els of vasor­e­lax­ant ­nitric oxide may ­account in part for the ­increased inci­dence of ­stroke and cor­o­nary heart dis­ease seen in these ­months.

    M3 - Article

    VL - 19

    SP - 351

    EP - 353

    JO - International Angiology

    JF - International Angiology

    SN - 0392-9590

    IS - 4

    ER -