TY - JOUR
T1 - Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
AU - Tobias, Deirdre K.
AU - Merino, Jordi
AU - Ahmad, Abrar
AU - Aiken, Catherine
AU - Benham, Jamie L.
AU - Bodhini, Dhanasekaran
AU - Clark, Amy L.
AU - Colclough, Kevin
AU - Corcoy, Rosa
AU - Cromer, Sara J.
AU - Duan, Daisy
AU - Felton, Jamie L.
AU - Francis, Ellen C.
AU - Gillard, Pieter
AU - Gingras, Véronique
AU - Gaillard, Romy
AU - Haider, Eram
AU - Hughes, Alice
AU - Ikle, Jennifer M.
AU - Jacobsen, Laura M.
AU - Kahkoska, Anna R.
AU - Kettunen, Jarno L. T.
AU - Kreienkamp, Raymond J.
AU - Lim, Lee-Ling
AU - Männistö, Jonna M. E.
AU - Massey, Robert
AU - Mclennan, Niamh-Maire
AU - Miller, Rachel G.
AU - Morieri, Mario Luca
AU - Most, Jasper
AU - Naylor, Rochelle N.
AU - Ozkan, Bige
AU - Patel, Kashyap Amratlal
AU - Pilla, Scott J.
AU - Prystupa, Katsiaryna
AU - Raghavan, Sridharan
AU - Rooney, Mary R.
AU - Schön, Martin
AU - Semnani-Azad, Zhila
AU - Sevilla- Gonzalez, Magdalena
AU - Svalastoga, Pernille
AU - Takele, Wubet Worku
AU - Tam, Claudia Ha-Ting
AU - Thuesen, Anne Cathrine B.
AU - Tosur, Mustafa
AU - Wallace, Amelia S.
AU - Wang, Caroline C.
AU - Dawed, Adem Y.
AU - Petrie, John R.
AU - Pearson, Ewan R.
AU - Franks, Paul W.
N1 - Copyright:
© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2023/10
Y1 - 2023/10
N2 - Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.
AB - Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.
KW - Medical research
KW - Translational research
U2 - 10.1038/s41591-023-02502-5
DO - 10.1038/s41591-023-02502-5
M3 - Review article
C2 - 37794253
SN - 1078-8956
VL - 29
SP - 2438
EP - 2457
JO - Nature Medicine
JF - Nature Medicine
IS - 10
ER -