Projects per year
Abstract
Cyclic di-GMP (c-di-GMP) is currently recognized as the most widely used intracellular signal molecule in prokaryotes, but roles in eukaryotes were only recently discovered. In the social amoeba Dictyostelium discoideum, c-di-GMP, produced by a prokaryote-type diguanylate cyclase, induces the differentiation of stalk cells, thereby enabling the formation of spore-bearing fruiting bodies. In this review, we summarize the currently known mechanisms that control the major life cycle transitions of Dictyostelium and focus particularly on the role of c-di-GMP in stalk formation. Stalk cell differentiation has characteristics of autophagic cell death, a process that also occurs in higher eukaryotes. We discuss the respective roles of c-di-GMP and of another signal molecule, differentiation-inducing factor 1, in autophagic cell death in vitro and in stalk formation in vivo.
Original language | English |
---|---|
Pages (from-to) | 27-31 |
Number of pages | 5 |
Journal | Journal of Bacteriology |
Volume | 198 |
Issue number | 1 |
Early online date | 26 May 2015 |
DOIs | |
Publication status | Published - Jan 2016 |
ASJC Scopus subject areas
- Microbiology
- Molecular Biology
Fingerprint
Dive into the research topics of 'Secreted cyclic di-GMP induces stalk cell differentiation in the eukaryote Dictyostelium discoideum'. Together they form a unique fingerprint.Projects
- 2 Finished
-
Molecular Mechanisms of Encystation and Sporulation (Senior Investigator Award)
Schaap, P. (Investigator)
1/02/14 → 31/01/20
Project: Research
-
The Molecular Basis of Phenotypic Evolution in Social Amoebas
Schaap, P. (Investigator)
Biotechnology and Biological Sciences Research Council
1/04/13 → 31/03/17
Project: Research