Selective inhibition of 6-phosphogluconate dehydrogenase from Trypanosoma brucei

Massimo Bertelli, Eman El-Bastawissy, Michael H Knaggs, Michael P Barrett, Stefania Hanau, Ian H Gilbert

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    15 Citations (Scopus)

    Abstract

    A number of triphenylmethane derivatives have been screened against 6-phosphogluconate dehydrogenase from Trypanosoma brucei and sheep liver. Some of these compounds show good inhibition of the enzymes and also selectivity towards the parasite enzyme. Modelling was undertaken to dock the compounds into the active sites of both enzymes. Using a combination of DOCK 3.5 and FLEXIDOCK a correlation was obtained between docking score and both activity for the enzymes and selectivity. Visualisation of the docked structures of the inhibitors in the active sites of the enzymes yielded a possible explanation of the selectivity for the parasite enzyme.

    Original languageEnglish
    Pages (from-to)465-475
    Number of pages11
    JournalJournal of Computer-Aided Molecular Design
    Volume15
    Issue number5
    DOIs
    Publication statusPublished - May 2001

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