Selective low-level leg muscle training alleviates dyspnea in patients with heart failure

Ainat Beniaminovitz, Chim C. Lang, John LaManca, Donna M. Mancini

    Research output: Contribution to journalArticlepeer-review

    58 Citations (Scopus)

    Abstract

    Objectives
    The purpose of this study was to demonstrate in patients with moderate to severe heart failure that exertional dyspnea can be alleviated by improving muscle function.
    Background
    Dyspnea is a frequent limiting symptom in patients with chronic heart failure (CHF). This sensation may originate from activation of receptors in the musculature rather than the lung.
    Methods
    To investigate whether dyspnea could be alleviated by selective changes in leg muscle function, we performed isolated lower-limb training in 17 patients with severe CHF. Eight patients learned guided imagery relaxation techniques and served as an active control group. Exercise training consisted of three months of low-level bicycle and treadmill exercise such that minute ventilation was <25 l/min. Leg calisthenics were also performed. Maximal and submaximal exercise performance, respiratory and quadriceps muscle strength and endurance and quality-of-life and dyspnea scales were measured before and after each intervention. Metabolic stress testing (VO2), pulmonary function tests and isokinetic strength testing were also performed.
    Results
    In the active control group, no changes in leg muscle function, pulmonary function, maximal and submaximal exercise performance or quality-of-life questionnaires were observed. In the training group, peak torque of leg flexors (pre: 39 ± 15 ft-lb; post: 50 ± 13 ft-lb; p < 0.002) increased and the fatigue ratio decreased, indicating improved strength and endurance of the leg muscles. Maximal inspiratory and expiratory mouth pressures and maximum voluntary ventilation were unchanged. Peak VO2 was increased (pre:12 ± 2.2 ml/kg/min; post: 14 ± 2.6 ml/kg/min) as well as the duration of exercise at 70% peak VO2 increased (pre: 11.5 ± 3.1 min; post: 21.5 ± 5.4 min; p < 0.003). Perceived dyspnea during the submaximal testing was decreased. Minnesota Living with Heart Failure Score, Guyatt Dyspnea Scale, and the Transitional Dyspnea Index were all improved with training (all p < 0.05).
    Conclusions
    We concluded that improvement of limb muscle function alleviates dyspnea and improves exercise performance in patients with CHF.
    Original languageEnglish
    Pages (from-to)1602-1608
    Number of pages7
    JournalJournal of the American College of Cardiology
    Volume40
    Issue number9
    DOIs
    Publication statusPublished - 6 Nov 2002

    Fingerprint Dive into the research topics of 'Selective low-level leg muscle training alleviates dyspnea in patients with heart failure'. Together they form a unique fingerprint.

    Cite this