Depolarization of an individual mitochondrion or small clusters of mitochondria within cells has been achieved using a photoactivatable probe. The probe is targeted to the matrix of the mitochondrion by an alkyltriphenylphosphonium lipophilic cation and releases the protonophore 2,4-dinitrophenol locally in predetermined regions in response to directed irradiation with UV light via a local photolysis system. This also provides a proof of principle for the general temporally and spatially controlled release of bioactive molecules, pharmacophores, or toxins to mitochondria with tissue, cell, or mitochondrion specificity.
|Number of pages||4|
|Journal||Journal of the American Chemical Society|
|Early online date||22 Dec 2011|
|Publication status||Published - 18 Jan 2012|
ASJC Scopus subject areas
- Colloid and Surface Chemistry