Sensitisation to the acrylate co-polymers glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol®) is rare

Livia F. Soriano; M. M.U. Chowdhury; Philippa Cousen; Simon Dawe; Sharizan A. Ghaffar; Adam Haworth; Catherine R. Holden; Aoife Hollywood; Graham A. Johnston; Stephen Kirk; Avad A. Mughal; David I. Orton; Robin Parker; Asha Rajeev; Krisztina Scharrer; Aparna Sinha; Natalie M. Stone; Donna Thompson; Sarah Wakelin; Heather Whitehouse; Catriona Wootton; Deirdre A. Buckley

doi:10.1111/cod.14679

Sensitisation to the acrylate co-polymers glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol®) is rare

Livia F. Soriano (Lead / Corresponding author), M. M.U. Chowdhury, Philippa Cousen, Simon Dawe, Sharizan A. Ghaffar, Adam Haworth, Catherine R. Holden, Aoife Hollywood, Graham A. Johnston, Stephen Kirk, Avad A. Mughal, David I. Orton, Robin Parker, Asha Rajeev, Krisztina Scharrer, Aparna Sinha, Natalie M. Stone, Donna Thompson, Sarah Wakelin, Heather WhitehouseCatriona Wootton, Deirdre A. Buckley

Undergraduate Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background

Acrylate polymers and cross-polymers (ACPs) are frequently used cosmetic ingredients. The British Society for Cutaneous Allergy (BSCA) and the UK Cosmetic, Toiletry and Perfumery Association (CTPA) collaborated to investigate the allergenic potential of three commonly-used ACPs.

Objectives

The objective of this study is to determine the prevalence of allergic contact dermatitis (ACD) to three ACPs: glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate, and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol®).

Materials and Methods

The BSCA prospectively audited data collected from 20 centres in the UK and Ireland between 1st September 2021 and 1st September 2022. Patients with suspected ACD to (meth)acrylates, with facial dermatitis, or consecutive patients, were patch tested to glyceryl acrylate/acrylic acid co-polymer 10% aqueous (aq.) sodium polyacrylate 2% aq., and to acrylates/C10-30 alkyl acrylate cross-polymer 2% aq. (Carbopol®). The frequencies of positive, irritant, and doubtful reactions were recorded.

Results

In total, 1302 patients were patch tested. To glyceryl acrylate/acrylic acid co-polymer, there was one doubtful reaction in a patient allergic to multiple (meth)acrylates, and one irritant. To sodium polyacrylate, there were four irritant reactions, one doubtful, and one positive reaction; in all cases, relevance was unknown and there was no demonstrable (meth)acrylate allergy. There were no reactions to Carbopol®.

Conclusions

Sensitisation to these concentrations of the three tested ACPs is rare. Elicitation of dermatitis in (meth)acrylate-sensitised patients by exposure to these three ACPs appears unlikely.

Original language	English
Pages (from-to)	491-496
Number of pages	6
Journal	Contact Dermatitis
Volume	91
Issue number	6
Early online date	26 Aug 2024
DOIs	https://doi.org/10.1111/cod.14679
Publication status	Published - 5 Nov 2024

Keywords

acrylate co-polymers
acrylates
allergic
contact dermatitis

ASJC Scopus subject areas

Immunology and Allergy
Dermatology

Access to Document

10.1111/cod.14679

Cite this

Soriano, L. F., Chowdhury, M. M. U., Cousen, P., Dawe, S., Ghaffar, S. A., Haworth, A., Holden, C. R., Hollywood, A., Johnston, G. A., Kirk, S., Mughal, A. A., Orton, D. I., Parker, R., Rajeev, A., Scharrer, K., Sinha, A., Stone, N. M., Thompson, D., Wakelin, S., ... Buckley, D. A. (2024). Sensitisation to the acrylate co-polymers glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol®) is rare. Contact Dermatitis, 91(6), 491-496. https://doi.org/10.1111/cod.14679

@article{485a505cfc684830abeed9e47d061da0,

title = "Sensitisation to the acrylate co-polymers glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol{\textregistered}) is rare",

abstract = "Background Acrylate polymers and cross-polymers (ACPs) are frequently used cosmetic ingredients. The British Society for Cutaneous Allergy (BSCA) and the UK Cosmetic, Toiletry and Perfumery Association (CTPA) collaborated to investigate the allergenic potential of three commonly-used ACPs. Objectives The objective of this study is to determine the prevalence of allergic contact dermatitis (ACD) to three ACPs: glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate, and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol{\textregistered}). Materials and Methods The BSCA prospectively audited data collected from 20 centres in the UK and Ireland between 1st September 2021 and 1st September 2022. Patients with suspected ACD to (meth)acrylates, with facial dermatitis, or consecutive patients, were patch tested to glyceryl acrylate/acrylic acid co-polymer 10% aqueous (aq.) sodium polyacrylate 2% aq., and to acrylates/C10-30 alkyl acrylate cross-polymer 2% aq. (Carbopol{\textregistered}). The frequencies of positive, irritant, and doubtful reactions were recorded. Results In total, 1302 patients were patch tested. To glyceryl acrylate/acrylic acid co-polymer, there was one doubtful reaction in a patient allergic to multiple (meth)acrylates, and one irritant. To sodium polyacrylate, there were four irritant reactions, one doubtful, and one positive reaction; in all cases, relevance was unknown and there was no demonstrable (meth)acrylate allergy. There were no reactions to Carbopol{\textregistered}. Conclusions Sensitisation to these concentrations of the three tested ACPs is rare. Elicitation of dermatitis in (meth)acrylate-sensitised patients by exposure to these three ACPs appears unlikely.",

keywords = "acrylate co-polymers, acrylates, allergic, contact dermatitis",

author = "Soriano, {Livia F.} and Chowdhury, {M. M.U.} and Philippa Cousen and Simon Dawe and Ghaffar, {Sharizan A.} and Adam Haworth and Holden, {Catherine R.} and Aoife Hollywood and Johnston, {Graham A.} and Stephen Kirk and Mughal, {Avad A.} and Orton, {David I.} and Robin Parker and Asha Rajeev and Krisztina Scharrer and Aparna Sinha and Stone, {Natalie M.} and Donna Thompson and Sarah Wakelin and Heather Whitehouse and Catriona Wootton and Buckley, {Deirdre A.}",

note = "Publisher Copyright: {\textcopyright} 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2024",

month = nov,

day = "5",

doi = "10.1111/cod.14679",

language = "English",

volume = "91",

pages = "491--496",

journal = "Contact Dermatitis",

issn = "0105-1873",

publisher = "Wiley-Blackwell",

number = "6",

}

Soriano, LF, Chowdhury, MMU, Cousen, P, Dawe, S, Ghaffar, SA, Haworth, A, Holden, CR, Hollywood, A, Johnston, GA, Kirk, S, Mughal, AA, Orton, DI, Parker, R, Rajeev, A, Scharrer, K, Sinha, A, Stone, NM, Thompson, D, Wakelin, S, Whitehouse, H, Wootton, C & Buckley, DA 2024, 'Sensitisation to the acrylate co-polymers glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol®) is rare', Contact Dermatitis, vol. 91, no. 6, pp. 491-496. https://doi.org/10.1111/cod.14679

Sensitisation to the acrylate co-polymers glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol®) is rare. / Soriano, Livia F. (Lead / Corresponding author); Chowdhury, M. M.U.; Cousen, Philippa et al.
In: Contact Dermatitis, Vol. 91, No. 6, 05.11.2024, p. 491-496.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Sensitisation to the acrylate co-polymers glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol®) is rare

AU - Soriano, Livia F.

AU - Chowdhury, M. M.U.

AU - Cousen, Philippa

AU - Dawe, Simon

AU - Ghaffar, Sharizan A.

AU - Haworth, Adam

AU - Holden, Catherine R.

AU - Hollywood, Aoife

AU - Johnston, Graham A.

AU - Kirk, Stephen

AU - Mughal, Avad A.

AU - Orton, David I.

AU - Parker, Robin

AU - Rajeev, Asha

AU - Scharrer, Krisztina

AU - Sinha, Aparna

AU - Stone, Natalie M.

AU - Thompson, Donna

AU - Wakelin, Sarah

AU - Whitehouse, Heather

AU - Wootton, Catriona

AU - Buckley, Deirdre A.

PY - 2024/11/5

Y1 - 2024/11/5

N2 - Background Acrylate polymers and cross-polymers (ACPs) are frequently used cosmetic ingredients. The British Society for Cutaneous Allergy (BSCA) and the UK Cosmetic, Toiletry and Perfumery Association (CTPA) collaborated to investigate the allergenic potential of three commonly-used ACPs. Objectives The objective of this study is to determine the prevalence of allergic contact dermatitis (ACD) to three ACPs: glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate, and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol®). Materials and Methods The BSCA prospectively audited data collected from 20 centres in the UK and Ireland between 1st September 2021 and 1st September 2022. Patients with suspected ACD to (meth)acrylates, with facial dermatitis, or consecutive patients, were patch tested to glyceryl acrylate/acrylic acid co-polymer 10% aqueous (aq.) sodium polyacrylate 2% aq., and to acrylates/C10-30 alkyl acrylate cross-polymer 2% aq. (Carbopol®). The frequencies of positive, irritant, and doubtful reactions were recorded. Results In total, 1302 patients were patch tested. To glyceryl acrylate/acrylic acid co-polymer, there was one doubtful reaction in a patient allergic to multiple (meth)acrylates, and one irritant. To sodium polyacrylate, there were four irritant reactions, one doubtful, and one positive reaction; in all cases, relevance was unknown and there was no demonstrable (meth)acrylate allergy. There were no reactions to Carbopol®. Conclusions Sensitisation to these concentrations of the three tested ACPs is rare. Elicitation of dermatitis in (meth)acrylate-sensitised patients by exposure to these three ACPs appears unlikely.

AB - Background Acrylate polymers and cross-polymers (ACPs) are frequently used cosmetic ingredients. The British Society for Cutaneous Allergy (BSCA) and the UK Cosmetic, Toiletry and Perfumery Association (CTPA) collaborated to investigate the allergenic potential of three commonly-used ACPs. Objectives The objective of this study is to determine the prevalence of allergic contact dermatitis (ACD) to three ACPs: glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate, and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol®). Materials and Methods The BSCA prospectively audited data collected from 20 centres in the UK and Ireland between 1st September 2021 and 1st September 2022. Patients with suspected ACD to (meth)acrylates, with facial dermatitis, or consecutive patients, were patch tested to glyceryl acrylate/acrylic acid co-polymer 10% aqueous (aq.) sodium polyacrylate 2% aq., and to acrylates/C10-30 alkyl acrylate cross-polymer 2% aq. (Carbopol®). The frequencies of positive, irritant, and doubtful reactions were recorded. Results In total, 1302 patients were patch tested. To glyceryl acrylate/acrylic acid co-polymer, there was one doubtful reaction in a patient allergic to multiple (meth)acrylates, and one irritant. To sodium polyacrylate, there were four irritant reactions, one doubtful, and one positive reaction; in all cases, relevance was unknown and there was no demonstrable (meth)acrylate allergy. There were no reactions to Carbopol®. Conclusions Sensitisation to these concentrations of the three tested ACPs is rare. Elicitation of dermatitis in (meth)acrylate-sensitised patients by exposure to these three ACPs appears unlikely.

KW - acrylate co-polymers

KW - acrylates

KW - allergic

KW - contact dermatitis

U2 - 10.1111/cod.14679

DO - 10.1111/cod.14679

M3 - Article

C2 - 39187930

AN - SCOPUS:85202054013

SN - 0105-1873

VL - 91

SP - 491

EP - 496

JO - Contact Dermatitis

JF - Contact Dermatitis

IS - 6

ER -

Sensitisation to the acrylate co-polymers glyceryl acrylate/acrylic acid co-polymer, sodium polyacrylate and acrylates/C10-30 alkyl acrylate cross-polymer (Carbopol®) is rare

Abstract

Keywords

ASJC Scopus subject areas

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