Sensitive protein alignments at tree-of-life scale using DIAMOND

Benjamin Buchfink; Klaus Reuter; Hajk-Georg Drost

doi:10.1038/s41592-021-01101-x

Sensitive protein alignments at tree-of-life scale using DIAMOND

Benjamin Buchfink, Klaus Reuter, Hajk-Georg Drost (Lead / Corresponding author)

Computational Biology

Research output: Contribution to journal › Article › peer-review

1382 Citations (Scopus)

37 Downloads (Pure)

Abstract

We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP.

Original language	English
Pages (from-to)	366-368
Number of pages	15
Journal	Nature Methods
Volume	18
Issue number	4
Early online date	7 Apr 2021
DOIs	https://doi.org/10.1038/s41592-021-01101-x
Publication status	Published - Apr 2021

ASJC Scopus subject areas

Biotechnology
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1038/s41592-021-01101-xLicence: CC BY

Final published versionFinal published version, 2.93 MBLicence: CC BY

Cite this

@article{e3ca3371a7d545bb903de6e8a6451ff3,

title = "Sensitive protein alignments at tree-of-life scale using DIAMOND",

abstract = "We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP.",

author = "Benjamin Buchfink and Klaus Reuter and Hajk-Georg Drost",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = apr,

doi = "10.1038/s41592-021-01101-x",

language = "English",

volume = "18",

pages = "366--368",

journal = "Nature Methods",

issn = "1548-7091",

publisher = "Nature Research",

number = "4",

}

TY - JOUR

T1 - Sensitive protein alignments at tree-of-life scale using DIAMOND

AU - Buchfink, Benjamin

AU - Reuter, Klaus

AU - Drost, Hajk-Georg

PY - 2021/4

Y1 - 2021/4

N2 - We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP.

AB - We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP.

UR - http://www.scopus.com/inward/record.url?scp=85103994908&partnerID=8YFLogxK

U2 - 10.1038/s41592-021-01101-x

DO - 10.1038/s41592-021-01101-x

M3 - Article

C2 - 33828273

AN - SCOPUS:85103994908

SN - 1548-7091

VL - 18

SP - 366

EP - 368

JO - Nature Methods

JF - Nature Methods

IS - 4

ER -

Sensitive protein alignments at tree-of-life scale using DIAMOND

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this