Sensitive protein alignments at tree-of-life scale using DIAMOND

Benjamin Buchfink; Klaus Reuter; Hajk-Georg Drost

doi:10.1038/s41592-021-01101-x

Sensitive protein alignments at tree-of-life scale using DIAMOND

Benjamin Buchfink
, Klaus Reuter
, Hajk-Georg Drost (Lead / Corresponding author)

Computational Biology

Research output: Contribution to journal › Article › peer-review

3316 Citations (Scopus)

232 Downloads (Pure)

Abstract

We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP.

Original language	English
Pages (from-to)	366-368
Number of pages	15
Journal	Nature Methods
Volume	18
Issue number	4
Early online date	7 Apr 2021
DOIs	https://doi.org/10.1038/s41592-021-01101-x
Publication status	Published - Apr 2021

ASJC Scopus subject areas

Biotechnology
Biochemistry
Molecular Biology
Cell Biology

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10.1038/s41592-021-01101-xLicence: CC BY

Final published versionFinal published version, 2.93 MBLicence: CC BY

Cite this

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Sensitive protein alignments at tree-of-life scale using DIAMOND

Abstract

ASJC Scopus subject areas

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