TY - JOUR
T1 - Serological markers of Chlamydia pneumoniae infection in men and women and subsequent coronary events: The Scottish Heart Health Study cohort
AU - Tavendale, Roger
AU - Parratt, David
AU - Pringle, Stuart
AU - A'Brook, Richard
AU - Tunstall-Pedoe, Hugh
N1 -
dc.publisher: Oxford University Press
HTP was senior author and grantholder. A successful collaboration with microbiologists exploiting archived serum saved from a large cohort study. This linked the occurrence of CV events with infection/inflammation, suggesting Chlamydia as a link, for the first time.
PY - 2002
Y1 - 2002
N2 - Aims To investigate the relationship between serum markers of Chlamydia pneumoniae infection and subsequent coronary events. Methods and Results In a nested case-control study, based on the Scottish Heart Health Study cohort, we estimated IgG, IgA and IgM antibodies to C. pneumoniae, and circulating immune complexes containing C. pneumoniae antigen in baseline serum samples from 217 cases experiencing a subsequent coronary event during follow-up (mean 7·5 years) and from their matched controls. In men, the proportion of specimens positive for IgG, IgA and IgM antibodies showed no case-control differences (80% vs 80%, 57% vs 53% and 3% vs 3%, respectively). The odds ratio for a coronary event was 1·00 (95% confidence interval 0·59–1·69) for the presence of IgG antibodies to C. pneumoniae; 1·21 (0·76–1·92) for IgA and 0·75 (0·17–3·35) for IgM. Similar results were seen in women. The proportion of specimens with circulating immune complexes with C. pneumoniae antigen also showed no case-control differences (12% vs 12%, both sexes combined) with an odds ratio of 1·00 (0·57–1·76). Conclusion Prior infection with C. pneumoniae, as estimated by these markers, does not appear to be a risk factor for subsequent coronary heart disease.
AB - Aims To investigate the relationship between serum markers of Chlamydia pneumoniae infection and subsequent coronary events. Methods and Results In a nested case-control study, based on the Scottish Heart Health Study cohort, we estimated IgG, IgA and IgM antibodies to C. pneumoniae, and circulating immune complexes containing C. pneumoniae antigen in baseline serum samples from 217 cases experiencing a subsequent coronary event during follow-up (mean 7·5 years) and from their matched controls. In men, the proportion of specimens positive for IgG, IgA and IgM antibodies showed no case-control differences (80% vs 80%, 57% vs 53% and 3% vs 3%, respectively). The odds ratio for a coronary event was 1·00 (95% confidence interval 0·59–1·69) for the presence of IgG antibodies to C. pneumoniae; 1·21 (0·76–1·92) for IgA and 0·75 (0·17–3·35) for IgM. Similar results were seen in women. The proportion of specimens with circulating immune complexes with C. pneumoniae antigen also showed no case-control differences (12% vs 12%, both sexes combined) with an odds ratio of 1·00 (0·57–1·76). Conclusion Prior infection with C. pneumoniae, as estimated by these markers, does not appear to be a risk factor for subsequent coronary heart disease.
KW - Coronary artery disease
KW - Chlamydia pneumoniae infection
KW - Epidemiology immune complexes
U2 - 10.1053/euhj.2001.2778
DO - 10.1053/euhj.2001.2778
M3 - Article
SN - 0195-668X
VL - 23
SP - 301
EP - 307
JO - European Heart Journal
JF - European Heart Journal
IS - 4
ER -