Serological markers of Chlamydia pneumoniae infection in men and women and subsequent coronary events: The Scottish Heart Health Study cohort

Roger Tavendale, David Parratt, Stuart Pringle, Richard A'Brook, Hugh Tunstall-Pedoe

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    Aims To investigate the relationship between serum markers of Chlamydia pneumoniae infection and subsequent coronary events. Methods and Results In a nested case-control study, based on the Scottish Heart Health Study cohort, we estimated IgG, IgA and IgM antibodies to C. pneumoniae, and circulating immune complexes containing C. pneumoniae antigen in baseline serum samples from 217 cases experiencing a subsequent coronary event during follow-up (mean 7·5 years) and from their matched controls. In men, the proportion of specimens positive for IgG, IgA and IgM antibodies showed no case-control differences (80% vs 80%, 57% vs 53% and 3% vs 3%, respectively). The odds ratio for a coronary event was 1·00 (95% confidence interval 0·59–1·69) for the presence of IgG antibodies to C. pneumoniae; 1·21 (0·76–1·92) for IgA and 0·75 (0·17–3·35) for IgM. Similar results were seen in women. The proportion of specimens with circulating immune complexes with C. pneumoniae antigen also showed no case-control differences (12% vs 12%, both sexes combined) with an odds ratio of 1·00 (0·57–1·76). Conclusion Prior infection with C. pneumoniae, as estimated by these markers, does not appear to be a risk factor for subsequent coronary heart disease.
    Original languageEnglish
    Pages (from-to)301-307
    Number of pages7
    JournalEuropean Heart Journal
    Volume23
    Issue number4
    DOIs
    Publication statusPublished - 2002

    Fingerprint

    Chlamydophila pneumoniae
    Chlamydia Infections
    Cohort Studies
    Health
    Immunoglobulin A
    Immunoglobulin M
    Immunoglobulin G
    Antigen-Antibody Complex
    Antibodies
    Odds Ratio
    Antigens
    Coronary Disease
    Case-Control Studies
    Biomarkers
    Confidence Intervals
    Infection
    Serum

    Keywords

    • Coronary artery disease
    • Chlamydia pneumoniae infection
    • Epidemiology immune complexes

    Cite this

    @article{d93d0f153dd14307a720e4f613fa5906,
    title = "Serological markers of Chlamydia pneumoniae infection in men and women and subsequent coronary events: The Scottish Heart Health Study cohort",
    abstract = "Aims To investigate the relationship between serum markers of Chlamydia pneumoniae infection and subsequent coronary events. Methods and Results In a nested case-control study, based on the Scottish Heart Health Study cohort, we estimated IgG, IgA and IgM antibodies to C. pneumoniae, and circulating immune complexes containing C. pneumoniae antigen in baseline serum samples from 217 cases experiencing a subsequent coronary event during follow-up (mean 7·5 years) and from their matched controls. In men, the proportion of specimens positive for IgG, IgA and IgM antibodies showed no case-control differences (80{\%} vs 80{\%}, 57{\%} vs 53{\%} and 3{\%} vs 3{\%}, respectively). The odds ratio for a coronary event was 1·00 (95{\%} confidence interval 0·59–1·69) for the presence of IgG antibodies to C. pneumoniae; 1·21 (0·76–1·92) for IgA and 0·75 (0·17–3·35) for IgM. Similar results were seen in women. The proportion of specimens with circulating immune complexes with C. pneumoniae antigen also showed no case-control differences (12{\%} vs 12{\%}, both sexes combined) with an odds ratio of 1·00 (0·57–1·76). Conclusion Prior infection with C. pneumoniae, as estimated by these markers, does not appear to be a risk factor for subsequent coronary heart disease.",
    keywords = "Coronary artery disease, Chlamydia pneumoniae infection, Epidemiology immune complexes",
    author = "Roger Tavendale and David Parratt and Stuart Pringle and Richard A'Brook and Hugh Tunstall-Pedoe",
    note = "dc.publisher: Oxford University Press HTP was senior author and grantholder. A successful collaboration with microbiologists exploiting archived serum saved from a large cohort study. This linked the occurrence of CV events with infection/inflammation, suggesting Chlamydia as a link, for the first time.",
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    language = "English",
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    Serological markers of Chlamydia pneumoniae infection in men and women and subsequent coronary events: The Scottish Heart Health Study cohort. / Tavendale, Roger; Parratt, David; Pringle, Stuart; A'Brook, Richard; Tunstall-Pedoe, Hugh.

    In: European Heart Journal, Vol. 23, No. 4, 2002, p. 301-307.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Serological markers of Chlamydia pneumoniae infection in men and women and subsequent coronary events: The Scottish Heart Health Study cohort

    AU - Tavendale, Roger

    AU - Parratt, David

    AU - Pringle, Stuart

    AU - A'Brook, Richard

    AU - Tunstall-Pedoe, Hugh

    N1 - dc.publisher: Oxford University Press HTP was senior author and grantholder. A successful collaboration with microbiologists exploiting archived serum saved from a large cohort study. This linked the occurrence of CV events with infection/inflammation, suggesting Chlamydia as a link, for the first time.

    PY - 2002

    Y1 - 2002

    N2 - Aims To investigate the relationship between serum markers of Chlamydia pneumoniae infection and subsequent coronary events. Methods and Results In a nested case-control study, based on the Scottish Heart Health Study cohort, we estimated IgG, IgA and IgM antibodies to C. pneumoniae, and circulating immune complexes containing C. pneumoniae antigen in baseline serum samples from 217 cases experiencing a subsequent coronary event during follow-up (mean 7·5 years) and from their matched controls. In men, the proportion of specimens positive for IgG, IgA and IgM antibodies showed no case-control differences (80% vs 80%, 57% vs 53% and 3% vs 3%, respectively). The odds ratio for a coronary event was 1·00 (95% confidence interval 0·59–1·69) for the presence of IgG antibodies to C. pneumoniae; 1·21 (0·76–1·92) for IgA and 0·75 (0·17–3·35) for IgM. Similar results were seen in women. The proportion of specimens with circulating immune complexes with C. pneumoniae antigen also showed no case-control differences (12% vs 12%, both sexes combined) with an odds ratio of 1·00 (0·57–1·76). Conclusion Prior infection with C. pneumoniae, as estimated by these markers, does not appear to be a risk factor for subsequent coronary heart disease.

    AB - Aims To investigate the relationship between serum markers of Chlamydia pneumoniae infection and subsequent coronary events. Methods and Results In a nested case-control study, based on the Scottish Heart Health Study cohort, we estimated IgG, IgA and IgM antibodies to C. pneumoniae, and circulating immune complexes containing C. pneumoniae antigen in baseline serum samples from 217 cases experiencing a subsequent coronary event during follow-up (mean 7·5 years) and from their matched controls. In men, the proportion of specimens positive for IgG, IgA and IgM antibodies showed no case-control differences (80% vs 80%, 57% vs 53% and 3% vs 3%, respectively). The odds ratio for a coronary event was 1·00 (95% confidence interval 0·59–1·69) for the presence of IgG antibodies to C. pneumoniae; 1·21 (0·76–1·92) for IgA and 0·75 (0·17–3·35) for IgM. Similar results were seen in women. The proportion of specimens with circulating immune complexes with C. pneumoniae antigen also showed no case-control differences (12% vs 12%, both sexes combined) with an odds ratio of 1·00 (0·57–1·76). Conclusion Prior infection with C. pneumoniae, as estimated by these markers, does not appear to be a risk factor for subsequent coronary heart disease.

    KW - Coronary artery disease

    KW - Chlamydia pneumoniae infection

    KW - Epidemiology immune complexes

    U2 - 10.1053/euhj.2001.2778

    DO - 10.1053/euhj.2001.2778

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    VL - 23

    SP - 301

    EP - 307

    JO - European Heart Journal

    JF - European Heart Journal

    SN - 0195-668X

    IS - 4

    ER -