TY - JOUR
T1 - Serum antinuclear autoantibodies are associated with measures of oxidative stress and lifestyle factors
T2 - analysis of LIPIDOGRAM2015 and LIPIDOGEN2015 studies
AU - Krzemień, Paweł
AU - Kasperczyk, Sławomir
AU - Banach, Maciej
AU - Kasperczyk, Aleksandra
AU - Dobrakowski, Michał
AU - Tomasik, Tomasz
AU - Windak, Adam
AU - Mastej, Mirosław
AU - Catapano, Alberico
AU - Ray, Kausik K.
AU - Mikhailidis, Dimitri P.
AU - Toth, Peter P.
AU - Howard, George
AU - Lip, Gregory Y. H.
AU - Tomaszewski, Maciej
AU - Charchar, Fadi J.
AU - Sattar, Naveed
AU - Williams, Bryan
AU - MacDonald, Thomas M.
AU - Penson, Peter E.
AU - Jóźwiak, Jacek J.
N1 - Funding Information:
The present study was an initiative of the Polish Lipid Association (PoLA) and the College of Fami- ly Physicians in Poland (CFPiP). The present study was funded by an unrestricted educational grant from Valeant (Warsaw, Poland). Valeant had no role in study design, data analysis, data interpretation, or writing of the report. The present study was also supported by the Silesian Analytical Laboratories (SLA), CHDE, BIO-RAD and Euroimmun.
Funding Information:
We would like to thank all the volunteer LIPIDOGRAM2015 investigators, all other volunteer staff and all participants. The list of the LIPIDOGRAM 2015 investigators is shown at the end of the article**. The present study was an initiative of the Polish Lipid Association (PoLA) and the College of Family Physicians in Poland (CFPiP). The present study was funded by an unrestricted educational grant from Valeant (Warsaw, Poland). Valeant had no role in study design, data analysis, data interpretation, or writing of the report. The present study was also supported by the Silesian Analytical Laboratories (SLA), CHDE, BIO-RAD and Euroimmun.
Publisher Copyright:
© 2021 Termedia & Banach.
PY - 2023/9/1
Y1 - 2023/9/1
N2 - Introduction: Oxidative stress is one of many factors suspected to promote antinuclear autoantibody (ANA) formation. Reactive oxygen species can induce changes in the antigenic structure of macromolecules, causing the immune system to treat them as “neo-antigens” and start production of autoantibodies. This study was designed to evaluate the relationship between oxidative stress markers, lifestyle factors and the detection of ANA. Material and methods: We examined measures of oxidative stress indices of free-radical damage to lipids and proteins, such as total oxidant status (TOS), concentration of protein thiol groups (PSH), and malondialdehyde (MDA), activity of superoxide dismutase (SOD) in 1731 serum samples. The parameters of the non-enzymatic antioxidant system, such as total antioxidant status (TAS) and uric acid (UA) concentration, were also measured and the oxidative stress index (OSI-index) was calculated. All samples were tested for the presence of ANA using an indirect immunofluorescence assay (IIFA). Results: The presence of ANA in women was associated with lower physical activity (p = 0.036), less frequent smoking (p = 0.007) and drinking of alcohol (p = 0.024) accompanied by significant changes in SOD isoenzymes activity (p < 0.001) and a higher uric acid (UA) concentration (p < 0.001). In ANA positive males we observed lower concentrations of PSH (p = 0.046) and increased concentrations of MDA (p = 0.047). Conclusions: The results indicate that local oxidative stress may be associated with increased probability of ANA formation in a sex-specific manner.
AB - Introduction: Oxidative stress is one of many factors suspected to promote antinuclear autoantibody (ANA) formation. Reactive oxygen species can induce changes in the antigenic structure of macromolecules, causing the immune system to treat them as “neo-antigens” and start production of autoantibodies. This study was designed to evaluate the relationship between oxidative stress markers, lifestyle factors and the detection of ANA. Material and methods: We examined measures of oxidative stress indices of free-radical damage to lipids and proteins, such as total oxidant status (TOS), concentration of protein thiol groups (PSH), and malondialdehyde (MDA), activity of superoxide dismutase (SOD) in 1731 serum samples. The parameters of the non-enzymatic antioxidant system, such as total antioxidant status (TAS) and uric acid (UA) concentration, were also measured and the oxidative stress index (OSI-index) was calculated. All samples were tested for the presence of ANA using an indirect immunofluorescence assay (IIFA). Results: The presence of ANA in women was associated with lower physical activity (p = 0.036), less frequent smoking (p = 0.007) and drinking of alcohol (p = 0.024) accompanied by significant changes in SOD isoenzymes activity (p < 0.001) and a higher uric acid (UA) concentration (p < 0.001). In ANA positive males we observed lower concentrations of PSH (p = 0.046) and increased concentrations of MDA (p = 0.047). Conclusions: The results indicate that local oxidative stress may be associated with increased probability of ANA formation in a sex-specific manner.
KW - antinuclear autoantibody
KW - lifestyle diseases
KW - oxidative stress
KW - reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=85172658088&partnerID=8YFLogxK
U2 - 10.5114/aoms/139313
DO - 10.5114/aoms/139313
M3 - Article
C2 - 37732061
AN - SCOPUS:85172658088
SN - 1734-1922
VL - 19
SP - 1214
EP - 1227
JO - Archives of Medical Science
JF - Archives of Medical Science
IS - 5
ER -