Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic elderly men

A. Ratkevicius; A. Joyson; I. Selmer; T. Dhanani; C. Grierson; A. M. Tommasi; A. DeVries; P. Rauchhaus; D. Crowther; S. Alesci; P. Yaworsky; F. Gilbert; T. W. Redpath; J. Brady; K. C.H. Fearon; D. M. Reid; C. A. Greig; H. Wackerhage

doi:10.1093/gerona/glr025

Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic elderly men

A. Ratkevicius, A. Joyson, I. Selmer, T. Dhanani, C. Grierson, A. M. Tommasi, A. DeVries, P. Rauchhaus, D. Crowther, S. Alesci, P. Yaworsky, F. Gilbert, T. W. Redpath, J. Brady, K. C.H. Fearon, D. M. Reid, C. A. Greig, H. Wackerhage

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Abstract

Sarcopenia is the loss of muscle size and function during ageing. The aim of this study was to test whether serum concentrations of myostatin and interacting proteins (GASP-1, FLRG, and follistatin) differed between young and elderly sarcopenic men. Isometric knee extensor maximal voluntary contraction and quadriceps cross-sectional area (magnetic resonance imaging measurement) were significantly higher in young (22 ± 2 years; 266 ± 54 N/m; 8,686 ± 1,154 mm2) than in mildly sarcopenic (69 ± 3 years; 183 ± 17 N/m; 6,621±718 mm2) and severely sarcopenic men (76 ± 6 years; 127 ± 23 N/m; 5,846 ± 591 mm2), respectively (p ≤ .01 for all comparisons). There was a trend (p = .06) toward higher FLRG in young (20 ± 8 ng/mL) than in mildly (15 ± 6 ng/mL) and severely sarcopenic men (17 ± 8 ng/mL). Myostatin, follistatin, GASP-1, tumor necrosis factor a, and interleukin-6 did not differ significantly. Insulin-like growth factor-1 and free testosterone were both significantly lower in sarcopenic men (p < .001). This suggests that altered serum concentrations of myostatin and myostatin-interacting proteins are not contributing to sarcopenia with the possible exception of FLRG.

Original language	English
Pages (from-to)	620-626
Number of pages	7
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	66 A
Issue number	6
DOIs	https://doi.org/10.1093/gerona/glr025
Publication status	Published - 7 Mar 2011

Keywords

Myostatin
Sarcopenia

ASJC Scopus subject areas

Ageing
Geriatrics and Gerontology

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10.1093/gerona/glr025

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Ratkevicius, A., Joyson, A., Selmer, I., Dhanani, T., Grierson, C., Tommasi, A. M., DeVries, A., Rauchhaus, P., Crowther, D., Alesci, S., Yaworsky, P., Gilbert, F., W. Redpath, T., Brady, J., Fearon, K. C. H., Reid, D. M., Greig, C. A., & Wackerhage, H. (2011). Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic elderly men. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 66 A(6), 620-626. https://doi.org/10.1093/gerona/glr025

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title = "Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic elderly men",

abstract = "Sarcopenia is the loss of muscle size and function during ageing. The aim of this study was to test whether serum concentrations of myostatin and interacting proteins (GASP-1, FLRG, and follistatin) differed between young and elderly sarcopenic men. Isometric knee extensor maximal voluntary contraction and quadriceps cross-sectional area (magnetic resonance imaging measurement) were significantly higher in young (22 ± 2 years; 266 ± 54 N/m; 8,686 ± 1,154 mm2) than in mildly sarcopenic (69 ± 3 years; 183 ± 17 N/m; 6,621±718 mm2) and severely sarcopenic men (76 ± 6 years; 127 ± 23 N/m; 5,846 ± 591 mm2), respectively (p ≤ .01 for all comparisons). There was a trend (p = .06) toward higher FLRG in young (20 ± 8 ng/mL) than in mildly (15 ± 6 ng/mL) and severely sarcopenic men (17 ± 8 ng/mL). Myostatin, follistatin, GASP-1, tumor necrosis factor a, and interleukin-6 did not differ significantly. Insulin-like growth factor-1 and free testosterone were both significantly lower in sarcopenic men (p < .001). This suggests that altered serum concentrations of myostatin and myostatin-interacting proteins are not contributing to sarcopenia with the possible exception of FLRG.",

keywords = "Myostatin, Sarcopenia",

author = "A. Ratkevicius and A. Joyson and I. Selmer and T. Dhanani and C. Grierson and Tommasi, {A. M.} and A. DeVries and P. Rauchhaus and D. Crowther and S. Alesci and P. Yaworsky and F. Gilbert and {W. Redpath}, T. and J. Brady and Fearon, {K. C.H.} and Reid, {D. M.} and Greig, {C. A.} and H. Wackerhage",

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doi = "10.1093/gerona/glr025",

language = "English",

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Ratkevicius, A, Joyson, A, Selmer, I, Dhanani, T, Grierson, C, Tommasi, AM, DeVries, A, Rauchhaus, P, Crowther, D, Alesci, S, Yaworsky, P, Gilbert, F, W. Redpath, T, Brady, J, Fearon, KCH, Reid, DM, Greig, CA & Wackerhage, H 2011, 'Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic elderly men', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 66 A, no. 6, pp. 620-626. https://doi.org/10.1093/gerona/glr025

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T1 - Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic elderly men

AU - Ratkevicius, A.

AU - Joyson, A.

AU - Selmer, I.

AU - Dhanani, T.

AU - Grierson, C.

AU - Tommasi, A. M.

AU - DeVries, A.

AU - Rauchhaus, P.

AU - Crowther, D.

AU - Alesci, S.

AU - Yaworsky, P.

AU - Gilbert, F.

AU - W. Redpath, T.

AU - Brady, J.

AU - Fearon, K. C.H.

AU - Reid, D. M.

AU - Greig, C. A.

AU - Wackerhage, H.

PY - 2011/3/7

Y1 - 2011/3/7

N2 - Sarcopenia is the loss of muscle size and function during ageing. The aim of this study was to test whether serum concentrations of myostatin and interacting proteins (GASP-1, FLRG, and follistatin) differed between young and elderly sarcopenic men. Isometric knee extensor maximal voluntary contraction and quadriceps cross-sectional area (magnetic resonance imaging measurement) were significantly higher in young (22 ± 2 years; 266 ± 54 N/m; 8,686 ± 1,154 mm2) than in mildly sarcopenic (69 ± 3 years; 183 ± 17 N/m; 6,621±718 mm2) and severely sarcopenic men (76 ± 6 years; 127 ± 23 N/m; 5,846 ± 591 mm2), respectively (p ≤ .01 for all comparisons). There was a trend (p = .06) toward higher FLRG in young (20 ± 8 ng/mL) than in mildly (15 ± 6 ng/mL) and severely sarcopenic men (17 ± 8 ng/mL). Myostatin, follistatin, GASP-1, tumor necrosis factor a, and interleukin-6 did not differ significantly. Insulin-like growth factor-1 and free testosterone were both significantly lower in sarcopenic men (p < .001). This suggests that altered serum concentrations of myostatin and myostatin-interacting proteins are not contributing to sarcopenia with the possible exception of FLRG.

AB - Sarcopenia is the loss of muscle size and function during ageing. The aim of this study was to test whether serum concentrations of myostatin and interacting proteins (GASP-1, FLRG, and follistatin) differed between young and elderly sarcopenic men. Isometric knee extensor maximal voluntary contraction and quadriceps cross-sectional area (magnetic resonance imaging measurement) were significantly higher in young (22 ± 2 years; 266 ± 54 N/m; 8,686 ± 1,154 mm2) than in mildly sarcopenic (69 ± 3 years; 183 ± 17 N/m; 6,621±718 mm2) and severely sarcopenic men (76 ± 6 years; 127 ± 23 N/m; 5,846 ± 591 mm2), respectively (p ≤ .01 for all comparisons). There was a trend (p = .06) toward higher FLRG in young (20 ± 8 ng/mL) than in mildly (15 ± 6 ng/mL) and severely sarcopenic men (17 ± 8 ng/mL). Myostatin, follistatin, GASP-1, tumor necrosis factor a, and interleukin-6 did not differ significantly. Insulin-like growth factor-1 and free testosterone were both significantly lower in sarcopenic men (p < .001). This suggests that altered serum concentrations of myostatin and myostatin-interacting proteins are not contributing to sarcopenia with the possible exception of FLRG.

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KW - Sarcopenia

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DO - 10.1093/gerona/glr025

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SN - 1079-5006

VL - 66 A

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JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

IS - 6

ER -

Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic elderly men

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Keywords

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