Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic elderly men

TY - JOUR

T1 - Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic elderly men

AU - Ratkevicius, A.

AU - Joyson, A.

AU - Selmer, I.

AU - Dhanani, T.

AU - Grierson, C.

AU - Tommasi, A. M.

AU - DeVries, A.

AU - Rauchhaus, P.

AU - Crowther, D.

AU - Alesci, S.

AU - Yaworsky, P.

AU - Gilbert, F.

AU - W. Redpath, T.

AU - Brady, J.

AU - Fearon, K. C.H.

AU - Reid, D. M.

AU - Greig, C. A.

AU - Wackerhage, H.

PY - 2011/3/7

Y1 - 2011/3/7

N2 - Sarcopenia is the loss of muscle size and function during ageing. The aim of this study was to test whether serum concentrations of myostatin and interacting proteins (GASP-1, FLRG, and follistatin) differed between young and elderly sarcopenic men. Isometric knee extensor maximal voluntary contraction and quadriceps cross-sectional area (magnetic resonance imaging measurement) were significantly higher in young (22 ± 2 years; 266 ± 54 N/m; 8,686 ± 1,154 mm2) than in mildly sarcopenic (69 ± 3 years; 183 ± 17 N/m; 6,621±718 mm2) and severely sarcopenic men (76 ± 6 years; 127 ± 23 N/m; 5,846 ± 591 mm2), respectively (p ≤ .01 for all comparisons). There was a trend (p = .06) toward higher FLRG in young (20 ± 8 ng/mL) than in mildly (15 ± 6 ng/mL) and severely sarcopenic men (17 ± 8 ng/mL). Myostatin, follistatin, GASP-1, tumor necrosis factor a, and interleukin-6 did not differ significantly. Insulin-like growth factor-1 and free testosterone were both significantly lower in sarcopenic men (p < .001). This suggests that altered serum concentrations of myostatin and myostatin-interacting proteins are not contributing to sarcopenia with the possible exception of FLRG.

AB - Sarcopenia is the loss of muscle size and function during ageing. The aim of this study was to test whether serum concentrations of myostatin and interacting proteins (GASP-1, FLRG, and follistatin) differed between young and elderly sarcopenic men. Isometric knee extensor maximal voluntary contraction and quadriceps cross-sectional area (magnetic resonance imaging measurement) were significantly higher in young (22 ± 2 years; 266 ± 54 N/m; 8,686 ± 1,154 mm2) than in mildly sarcopenic (69 ± 3 years; 183 ± 17 N/m; 6,621±718 mm2) and severely sarcopenic men (76 ± 6 years; 127 ± 23 N/m; 5,846 ± 591 mm2), respectively (p ≤ .01 for all comparisons). There was a trend (p = .06) toward higher FLRG in young (20 ± 8 ng/mL) than in mildly (15 ± 6 ng/mL) and severely sarcopenic men (17 ± 8 ng/mL). Myostatin, follistatin, GASP-1, tumor necrosis factor a, and interleukin-6 did not differ significantly. Insulin-like growth factor-1 and free testosterone were both significantly lower in sarcopenic men (p < .001). This suggests that altered serum concentrations of myostatin and myostatin-interacting proteins are not contributing to sarcopenia with the possible exception of FLRG.

KW - Myostatin

KW - Sarcopenia

UR - https://www.scopus.com/pages/publications/80051511849

U2 - 10.1093/gerona/glr025

DO - 10.1093/gerona/glr025

M3 - Article

C2 - 21382886

AN - SCOPUS:80051511849

SN - 1079-5006

VL - 66 A

SP - 620

EP - 626

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

IS - 6

ER -