TY - JOUR
T1 - Serum thyroid hormones in preterm infants and relationships to indices of severity of intercurrent illness
AU - Simpson, Judith
AU - Williams, Fiona L. R.
AU - Delahunty, Caroline
AU - van Toor, Hans
AU - Wu, S.-Y.
AU - Ogston, Simon A.
AU - Visser, Theo J.
AU - Hume, Robert
AU - Scottish Preterm Thyroid Group
PY - 2005/3
Y1 - 2005/3
N2 - The purpose of this study was to relate severity of illness at 1, 7, 14, and 28 postnatal days in preterm infants groups, 23 - 27 ;( n = 73), 28 - 30 ( n = 160), and 31 - 34 ( n = 208) wk gestation, to the corresponding sera levels of T-4, free T-4, T-4-binding globulin, TSH, T-3, rT(3), and T-4 sulfate. The British Association of Perinatal Medicine and Neonatal Nurses Association 1992 scoring categories ( published elsewhere) were used as an index of illness severity: level 1 ( maximal intensive care) was compared with level 2 ( high-dependency intensive care) combined with level 3 ( special care); infants were scored on 1, 7, 14, and 28 postnatal days. In level 1 infants, there were significant reductions in T-3 at 7 d ( 28 - 30 wk), 14, and 28 d ( 23 - 27 and 28 - 30 wk); T-4 at 7, 14, and 28 d ( 23 - 27 wk); at 14 and 28 d ( 28 - 30 wk); and at 7 d ( 31 - 34 wk); and free T-4 at 14 d ( 23 - 27 wk). TSH was unchanged in all groups at all ages and with reductions in T-4 and T-3 being the key features of severe illness in extreme preterm infants.
AB - The purpose of this study was to relate severity of illness at 1, 7, 14, and 28 postnatal days in preterm infants groups, 23 - 27 ;( n = 73), 28 - 30 ( n = 160), and 31 - 34 ( n = 208) wk gestation, to the corresponding sera levels of T-4, free T-4, T-4-binding globulin, TSH, T-3, rT(3), and T-4 sulfate. The British Association of Perinatal Medicine and Neonatal Nurses Association 1992 scoring categories ( published elsewhere) were used as an index of illness severity: level 1 ( maximal intensive care) was compared with level 2 ( high-dependency intensive care) combined with level 3 ( special care); infants were scored on 1, 7, 14, and 28 postnatal days. In level 1 infants, there were significant reductions in T-3 at 7 d ( 28 - 30 wk), 14, and 28 d ( 23 - 27 and 28 - 30 wk); T-4 at 7, 14, and 28 d ( 23 - 27 wk); at 14 and 28 d ( 28 - 30 wk); and at 7 d ( 31 - 34 wk); and free T-4 at 14 d ( 23 - 27 wk). TSH was unchanged in all groups at all ages and with reductions in T-4 and T-3 being the key features of severe illness in extreme preterm infants.
KW - Critical illness
KW - Premature infants
KW - Blood
KW - Severity of illness index
KW - Thyroid hormones blood
U2 - 10.1210/jc.2004-2091
DO - 10.1210/jc.2004-2091
M3 - Article
SN - 0021-972X
VL - 90
SP - 1271
EP - 1279
JO - Journal of Clinical Endocrinology & Metabolism
JF - Journal of Clinical Endocrinology & Metabolism
IS - 3
ER -