Serum thyroid hormones in preterm infants and relationships to indices of severity of intercurrent illness

Judith Simpson, Fiona L. R. Williams, Caroline Delahunty, Hans van Toor, S.-Y. Wu, Simon A. Ogston, Theo J. Visser, Robert Hume, Scottish Preterm Thyroid Group

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    63 Citations (Scopus)

    Abstract

    The purpose of this study was to relate severity of illness at 1, 7, 14, and 28 postnatal days in preterm infants groups, 23 - 27 ;( n = 73), 28 - 30 ( n = 160), and 31 - 34 ( n = 208) wk gestation, to the corresponding sera levels of T-4, free T-4, T-4-binding globulin, TSH, T-3, rT(3), and T-4 sulfate. The British Association of Perinatal Medicine and Neonatal Nurses Association 1992 scoring categories ( published elsewhere) were used as an index of illness severity: level 1 ( maximal intensive care) was compared with level 2 ( high-dependency intensive care) combined with level 3 ( special care); infants were scored on 1, 7, 14, and 28 postnatal days. In level 1 infants, there were significant reductions in T-3 at 7 d ( 28 - 30 wk), 14, and 28 d ( 23 - 27 and 28 - 30 wk); T-4 at 7, 14, and 28 d ( 23 - 27 wk); at 14 and 28 d ( 28 - 30 wk); and at 7 d ( 31 - 34 wk); and free T-4 at 14 d ( 23 - 27 wk). TSH was unchanged in all groups at all ages and with reductions in T-4 and T-3 being the key features of severe illness in extreme preterm infants.

    Original languageEnglish
    Pages (from-to)1271-1279
    Number of pages9
    JournalJournal of Clinical Endocrinology & Metabolism
    Volume90
    Issue number3
    DOIs
    Publication statusPublished - Mar 2005

    Keywords

    • Critical illness
    • Premature infants
    • Blood
    • Severity of illness index
    • Thyroid hormones blood

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