Setting our sights on infectious diseases

Manu De Rycker, David Horn, Bree Aldridge, Richard K. Amewu, Clifton E. Barry, Frederick S. Buckner, Sarah Cook, Michael A. J. Ferguson, Nathalie Gobeau, Jennifer Herrmann, Paul Herrling, William Hope, Jennifer Keiser, Maria Jose Lafuente-Monasterio, Paul D. Leeson, Didier Leroy, Ujjini H. Manjunatha, James McCarthy, Timothy J. Miles, Valerie MizrahiOlena Moshynets, Jacquin Niles, John P. Overington, John Pottage, Srinivasa P. S. Rao, Kevin D. Read, Isabela Ribeiro, Lynn L. Silver, Jen Southern, Thomas Spangenberg, Shyam Sundar, Caitlin Taylor, Wesley C. Van Voorhis, Nicholas J. White, Susan Wyllie, Paul G. Wyatt, Ian H. Gilbert

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Abstract

In May 2019, the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings.

Original languageEnglish
Pages (from-to)3-13
Number of pages11
JournalACS Infectious Diseases
Volume6
Early online date6 Dec 2019
DOIs
Publication statusPublished - 10 Jan 2020

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Drug Discovery
Communicable Diseases
Infectious Disease Medicine
Pharmacokinetics
Learning
Research
Pharmaceutical Preparations
Therapeutics

Keywords

  • drug discovery
  • neglected tropical diseases
  • low and middle income countries

Cite this

De Rycker, Manu ; Horn, David ; Aldridge, Bree ; Amewu, Richard K. ; Barry, Clifton E. ; Buckner, Frederick S. ; Cook, Sarah ; Ferguson, Michael A. J. ; Gobeau, Nathalie ; Herrmann, Jennifer ; Herrling, Paul ; Hope, William ; Keiser, Jennifer ; Lafuente-Monasterio, Maria Jose ; Leeson, Paul D. ; Leroy, Didier ; Manjunatha, Ujjini H. ; McCarthy, James ; Miles, Timothy J. ; Mizrahi, Valerie ; Moshynets, Olena ; Niles, Jacquin ; Overington, John P. ; Pottage, John ; Rao, Srinivasa P. S. ; Read, Kevin D. ; Ribeiro, Isabela ; Silver, Lynn L. ; Southern, Jen ; Spangenberg, Thomas ; Sundar, Shyam ; Taylor, Caitlin ; Van Voorhis, Wesley C. ; White, Nicholas J. ; Wyllie, Susan ; Wyatt, Paul G. ; Gilbert, Ian H. / Setting our sights on infectious diseases. In: ACS Infectious Diseases. 2020 ; Vol. 6. pp. 3-13.
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abstract = "In May 2019, the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings.",
keywords = "drug discovery, neglected tropical diseases, low and middle income countries",
author = "{De Rycker}, Manu and David Horn and Bree Aldridge and Amewu, {Richard K.} and Barry, {Clifton E.} and Buckner, {Frederick S.} and Sarah Cook and Ferguson, {Michael A. J.} and Nathalie Gobeau and Jennifer Herrmann and Paul Herrling and William Hope and Jennifer Keiser and Lafuente-Monasterio, {Maria Jose} and Leeson, {Paul D.} and Didier Leroy and Manjunatha, {Ujjini H.} and James McCarthy and Miles, {Timothy J.} and Valerie Mizrahi and Olena Moshynets and Jacquin Niles and Overington, {John P.} and John Pottage and Rao, {Srinivasa P. S.} and Read, {Kevin D.} and Isabela Ribeiro and Silver, {Lynn L.} and Jen Southern and Thomas Spangenberg and Shyam Sundar and Caitlin Taylor and {Van Voorhis}, {Wesley C.} and White, {Nicholas J.} and Susan Wyllie and Wyatt, {Paul G.} and Gilbert, {Ian H.}",
note = "The conference was in part supported by a Wellcome Trust Centre Award 203134/Z/16/Z. We would also like to acknowledge the following for providing travel bursaries to allow scientists from Low and Middle Income Countries to attend the meeting: the Bill & Melinda Gates Foundation (OPP1199837); Medicines for Malaria Venture; Novartis Institutes for Biomedical Research (NIBR); Drug for Neglected Diseases initiative.",
year = "2020",
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De Rycker, M, Horn, D, Aldridge, B, Amewu, RK, Barry, CE, Buckner, FS, Cook, S, Ferguson, MAJ, Gobeau, N, Herrmann, J, Herrling, P, Hope, W, Keiser, J, Lafuente-Monasterio, MJ, Leeson, PD, Leroy, D, Manjunatha, UH, McCarthy, J, Miles, TJ, Mizrahi, V, Moshynets, O, Niles, J, Overington, JP, Pottage, J, Rao, SPS, Read, KD, Ribeiro, I, Silver, LL, Southern, J, Spangenberg, T, Sundar, S, Taylor, C, Van Voorhis, WC, White, NJ, Wyllie, S, Wyatt, PG & Gilbert, IH 2020, 'Setting our sights on infectious diseases', ACS Infectious Diseases, vol. 6, pp. 3-13. https://doi.org/10.1021/acsinfecdis.9b00371

Setting our sights on infectious diseases. / De Rycker, Manu; Horn, David; Aldridge, Bree; Amewu, Richard K.; Barry, Clifton E.; Buckner, Frederick S.; Cook, Sarah; Ferguson, Michael A. J.; Gobeau, Nathalie; Herrmann, Jennifer; Herrling, Paul; Hope, William; Keiser, Jennifer; Lafuente-Monasterio, Maria Jose; Leeson, Paul D.; Leroy, Didier; Manjunatha, Ujjini H.; McCarthy, James; Miles, Timothy J.; Mizrahi, Valerie; Moshynets, Olena; Niles, Jacquin; Overington, John P.; Pottage, John; Rao, Srinivasa P. S.; Read, Kevin D.; Ribeiro, Isabela; Silver, Lynn L.; Southern, Jen; Spangenberg, Thomas; Sundar, Shyam; Taylor, Caitlin; Van Voorhis, Wesley C.; White, Nicholas J.; Wyllie, Susan; Wyatt, Paul G.; Gilbert, Ian H. (Lead / Corresponding author).

In: ACS Infectious Diseases, Vol. 6, 10.01.2020, p. 3-13.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Setting our sights on infectious diseases

AU - De Rycker, Manu

AU - Horn, David

AU - Aldridge, Bree

AU - Amewu, Richard K.

AU - Barry, Clifton E.

AU - Buckner, Frederick S.

AU - Cook, Sarah

AU - Ferguson, Michael A. J.

AU - Gobeau, Nathalie

AU - Herrmann, Jennifer

AU - Herrling, Paul

AU - Hope, William

AU - Keiser, Jennifer

AU - Lafuente-Monasterio, Maria Jose

AU - Leeson, Paul D.

AU - Leroy, Didier

AU - Manjunatha, Ujjini H.

AU - McCarthy, James

AU - Miles, Timothy J.

AU - Mizrahi, Valerie

AU - Moshynets, Olena

AU - Niles, Jacquin

AU - Overington, John P.

AU - Pottage, John

AU - Rao, Srinivasa P. S.

AU - Read, Kevin D.

AU - Ribeiro, Isabela

AU - Silver, Lynn L.

AU - Southern, Jen

AU - Spangenberg, Thomas

AU - Sundar, Shyam

AU - Taylor, Caitlin

AU - Van Voorhis, Wesley C.

AU - White, Nicholas J.

AU - Wyllie, Susan

AU - Wyatt, Paul G.

AU - Gilbert, Ian H.

N1 - The conference was in part supported by a Wellcome Trust Centre Award 203134/Z/16/Z. We would also like to acknowledge the following for providing travel bursaries to allow scientists from Low and Middle Income Countries to attend the meeting: the Bill & Melinda Gates Foundation (OPP1199837); Medicines for Malaria Venture; Novartis Institutes for Biomedical Research (NIBR); Drug for Neglected Diseases initiative.

PY - 2020/1/10

Y1 - 2020/1/10

N2 - In May 2019, the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings.

AB - In May 2019, the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings.

KW - drug discovery

KW - neglected tropical diseases

KW - low and middle income countries

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U2 - 10.1021/acsinfecdis.9b00371

DO - 10.1021/acsinfecdis.9b00371

M3 - Article

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SP - 3

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JO - ACS Infectious Diseases

JF - ACS Infectious Diseases

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