Setting our sights on infectious diseases

Manu De Rycker, David Horn, Bree Aldridge, Richard K. Amewu, Clifton E. Barry, Frederick S. Buckner, Sarah Cook, Michael A. J. Ferguson, Nathalie Gobeau, Jennifer Herrmann, Paul Herrling, William Hope, Jennifer Keiser, Maria Jose Lafuente-Monasterio, Paul D. Leeson, Didier Leroy, Ujjini H. Manjunatha, James McCarthy, Timothy J. Miles, Valerie MizrahiOlena Moshynets, Jacquin Niles, John P. Overington, John Pottage, Srinivasa P. S. Rao, Kevin D. Read, Isabela Ribeiro, Lynn L. Silver, Jen Southern, Thomas Spangenberg, Shyam Sundar, Caitlin Taylor, Wesley C. Van Voorhis, Nicholas J. White, Susan Wyllie, Paul G. Wyatt, Ian H. Gilbert

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Abstract

In May 2019, the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings.

Original languageEnglish
Pages (from-to)3-13
Number of pages11
JournalACS Infectious Diseases
Volume6
Early online date6 Dec 2019
DOIs
Publication statusPublished - 10 Jan 2020

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Keywords

  • drug discovery
  • neglected tropical diseases
  • low and middle income countries

Cite this

De Rycker, M., Horn, D., Aldridge, B., Amewu, R. K., Barry, C. E., Buckner, F. S., Cook, S., Ferguson, M. A. J., Gobeau, N., Herrmann, J., Herrling, P., Hope, W., Keiser, J., Lafuente-Monasterio, M. J., Leeson, P. D., Leroy, D., Manjunatha, U. H., McCarthy, J., Miles, T. J., ... Gilbert, I. H. (2020). Setting our sights on infectious diseases. ACS Infectious Diseases, 6, 3-13. https://doi.org/10.1021/acsinfecdis.9b00371