Seven newly identified loci for autoimmune thyroid disease

TY - JOUR

T1 - Seven newly identified loci for autoimmune thyroid disease

AU - Cooper, Jason D.

AU - Simmonds, Matthew J.

AU - Walker, Neil M.

AU - Burren, Oliver

AU - Brand, Oliver J.

AU - Guo, Hui

AU - Wallace, Chris

AU - Stevens, Helen

AU - Coleman, Gillian

AU - Wellcome Trust Case Control Consortium

AU - Franklyn, Jayne A.

AU - Todd, John A.

AU - Gough, Stephen C.L.

A2 - Mowat, Craig

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 × 10-6; a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases.

AB - Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 × 10-6; a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases.

UR - https://www.scopus.com/pages/publications/84869021173

U2 - 10.1093/hmg/dds357

DO - 10.1093/hmg/dds357

M3 - Article

C2 - 22922229

AN - SCOPUS:84869021173

SN - 0964-6906

VL - 21

SP - 5202

EP - 5208

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 23

ER -