Severe hypophosphataemia following ferric carboxymaltose infusion in paediatric patients with inflammatory bowel disease

Rachel Elizabeth Harris, Lawrence Armstrong, Lee Curtis, Vikki Garrick, Lisa Gervais, Rachel Tayler, Richard Hansen, Richard K. Russell

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

This case series describes the cases of three adolescent patients with established inflammatory bowel disease (IBD) who experienced significant hypophosphataemia following intravenous infusion of ferric carboxymaltose as treatment for iron deficiency anaemia. Hypophosphataemia may cause a diverse range of symptoms and may be difficult to diagnose clinically due to their non-specific nature. Checking a baseline phosphate (PO 4) prior to intravenous iron infusion may identify patients at higher risk for significant hypophosphataemia and perhaps allow the selection of an alternative iron preparation. The routine monitoring of PO 4 levels postinfusion presents a greater challenge; with cases of asymptomatic hypophosphataemia likely to be uncovered, as in case 3. Clinicians, patients and families should be aware of the symptoms of hypophosphataemia, and symptomatic patients should have bloods checked to allow prompt identification and correction of abnormalities where required. Review of guidelines surrounding intravenous iron infusion and management of hypophosphataemia in paediatric patients is now required.

Original languageEnglish
Pages (from-to)324-326
Number of pages3
JournalFrontline Gastroenterology
Volume11
Issue number4
Early online date3 Jul 2019
DOIs
Publication statusPublished - 1 Jul 2020

Keywords

  • inflammatory bowel disease
  • paediatric gastroenterology

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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