Severity of depression and risk for subsequent dementia: cohort studies in China and the UK

Ruoling Chen, Zhi Hu, Li Wei, Xia Qin, Cherie McCracken, John R. Copeland

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    Abstract

    Background

    Depression and dementia often exist concurrently. The associations of depressive syndromes and severity of depression with incident dementia have been little studied.

    Aims

    To determine the effects of depressive syndromes and cases of depression on the risk of incident dementia.

    Method

    Participants in China and the UK aged >= 65 years without dementia were interviewed using the Geriatric Mental State interview and re-interviewed I year later in 1254 Chinese, and 2 and 4 years later in 3341 and 2157 British participants respectively (Ageing in Liverpool Project Health Aspects: part of the Medical Research Council - Cognitive Function and Ageing study).

    Results

    Incident dementia was associated with only the most severe depressive syndromes in both Chinese and British participants. The risk of dementia increased, not in the less severe cases of depression but in the most severe cases. The multiple adjusted hazard ratio (HR)=5.44 (95% CI 1.67-17.8) for Chinese participants at 1-year follow-up, and HR=2.47 (95% CI 1.25-4.89) and 1 (95% Cl 1.18-5.80) for British participants at 2- and 4-year follow-up respectively. The effect was greater in younger participants.

    Conclusions

    Only the most severe syndromes and cases of depression are a risk factor for dementia.

    Declaration of interest

    None. Funding detailed in Acknowledgements.

    Original languageEnglish
    Pages (from-to)373-377
    Number of pages5
    JournalBritish Journal of Psychiatry
    Volume193
    Issue number5
    DOIs
    Publication statusPublished - Nov 2008

    Keywords

    • CORONARY-HEART-DISEASE
    • GERIATRIC MENTAL STATE
    • OLDER-PEOPLE
    • MRC-ALPHA
    • COMMUNITY RESIDENTS
    • ALZHEIMERS-DISEASE
    • POPULATION
    • PREVALENCE
    • METAANALYSIS
    • VALIDATION

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