Severity of depression and risk for subsequent dementia

cohort studies in China and the UK

Ruoling Chen, Zhi Hu, Li Wei, Xia Qin, Cherie McCracken, John R. Copeland

    Research output: Contribution to journalArticle

    73 Citations (Scopus)

    Abstract

    Background

    Depression and dementia often exist concurrently. The associations of depressive syndromes and severity of depression with incident dementia have been little studied.

    Aims

    To determine the effects of depressive syndromes and cases of depression on the risk of incident dementia.

    Method

    Participants in China and the UK aged >= 65 years without dementia were interviewed using the Geriatric Mental State interview and re-interviewed I year later in 1254 Chinese, and 2 and 4 years later in 3341 and 2157 British participants respectively (Ageing in Liverpool Project Health Aspects: part of the Medical Research Council - Cognitive Function and Ageing study).

    Results

    Incident dementia was associated with only the most severe depressive syndromes in both Chinese and British participants. The risk of dementia increased, not in the less severe cases of depression but in the most severe cases. The multiple adjusted hazard ratio (HR)=5.44 (95% CI 1.67-17.8) for Chinese participants at 1-year follow-up, and HR=2.47 (95% CI 1.25-4.89) and 1 (95% Cl 1.18-5.80) for British participants at 2- and 4-year follow-up respectively. The effect was greater in younger participants.

    Conclusions

    Only the most severe syndromes and cases of depression are a risk factor for dementia.

    Declaration of interest

    None. Funding detailed in Acknowledgements.

    Original languageEnglish
    Pages (from-to)373-377
    Number of pages5
    JournalBritish Journal of Psychiatry
    Volume193
    Issue number5
    DOIs
    Publication statusPublished - Nov 2008

    Keywords

    • CORONARY-HEART-DISEASE
    • GERIATRIC MENTAL STATE
    • OLDER-PEOPLE
    • MRC-ALPHA
    • COMMUNITY RESIDENTS
    • ALZHEIMERS-DISEASE
    • POPULATION
    • PREVALENCE
    • METAANALYSIS
    • VALIDATION

    Cite this

    Chen, Ruoling ; Hu, Zhi ; Wei, Li ; Qin, Xia ; McCracken, Cherie ; Copeland, John R. / Severity of depression and risk for subsequent dementia : cohort studies in China and the UK. In: British Journal of Psychiatry. 2008 ; Vol. 193, No. 5. pp. 373-377.
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    abstract = "BackgroundDepression and dementia often exist concurrently. The associations of depressive syndromes and severity of depression with incident dementia have been little studied.AimsTo determine the effects of depressive syndromes and cases of depression on the risk of incident dementia.MethodParticipants in China and the UK aged >= 65 years without dementia were interviewed using the Geriatric Mental State interview and re-interviewed I year later in 1254 Chinese, and 2 and 4 years later in 3341 and 2157 British participants respectively (Ageing in Liverpool Project Health Aspects: part of the Medical Research Council - Cognitive Function and Ageing study).ResultsIncident dementia was associated with only the most severe depressive syndromes in both Chinese and British participants. The risk of dementia increased, not in the less severe cases of depression but in the most severe cases. The multiple adjusted hazard ratio (HR)=5.44 (95{\%} CI 1.67-17.8) for Chinese participants at 1-year follow-up, and HR=2.47 (95{\%} CI 1.25-4.89) and 1 (95{\%} Cl 1.18-5.80) for British participants at 2- and 4-year follow-up respectively. The effect was greater in younger participants.ConclusionsOnly the most severe syndromes and cases of depression are a risk factor for dementia.Declaration of interestNone. Funding detailed in Acknowledgements.",
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    Severity of depression and risk for subsequent dementia : cohort studies in China and the UK. / Chen, Ruoling; Hu, Zhi; Wei, Li; Qin, Xia; McCracken, Cherie; Copeland, John R.

    In: British Journal of Psychiatry, Vol. 193, No. 5, 11.2008, p. 373-377.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Severity of depression and risk for subsequent dementia

    T2 - cohort studies in China and the UK

    AU - Chen, Ruoling

    AU - Hu, Zhi

    AU - Wei, Li

    AU - Qin, Xia

    AU - McCracken, Cherie

    AU - Copeland, John R.

    PY - 2008/11

    Y1 - 2008/11

    N2 - BackgroundDepression and dementia often exist concurrently. The associations of depressive syndromes and severity of depression with incident dementia have been little studied.AimsTo determine the effects of depressive syndromes and cases of depression on the risk of incident dementia.MethodParticipants in China and the UK aged >= 65 years without dementia were interviewed using the Geriatric Mental State interview and re-interviewed I year later in 1254 Chinese, and 2 and 4 years later in 3341 and 2157 British participants respectively (Ageing in Liverpool Project Health Aspects: part of the Medical Research Council - Cognitive Function and Ageing study).ResultsIncident dementia was associated with only the most severe depressive syndromes in both Chinese and British participants. The risk of dementia increased, not in the less severe cases of depression but in the most severe cases. The multiple adjusted hazard ratio (HR)=5.44 (95% CI 1.67-17.8) for Chinese participants at 1-year follow-up, and HR=2.47 (95% CI 1.25-4.89) and 1 (95% Cl 1.18-5.80) for British participants at 2- and 4-year follow-up respectively. The effect was greater in younger participants.ConclusionsOnly the most severe syndromes and cases of depression are a risk factor for dementia.Declaration of interestNone. Funding detailed in Acknowledgements.

    AB - BackgroundDepression and dementia often exist concurrently. The associations of depressive syndromes and severity of depression with incident dementia have been little studied.AimsTo determine the effects of depressive syndromes and cases of depression on the risk of incident dementia.MethodParticipants in China and the UK aged >= 65 years without dementia were interviewed using the Geriatric Mental State interview and re-interviewed I year later in 1254 Chinese, and 2 and 4 years later in 3341 and 2157 British participants respectively (Ageing in Liverpool Project Health Aspects: part of the Medical Research Council - Cognitive Function and Ageing study).ResultsIncident dementia was associated with only the most severe depressive syndromes in both Chinese and British participants. The risk of dementia increased, not in the less severe cases of depression but in the most severe cases. The multiple adjusted hazard ratio (HR)=5.44 (95% CI 1.67-17.8) for Chinese participants at 1-year follow-up, and HR=2.47 (95% CI 1.25-4.89) and 1 (95% Cl 1.18-5.80) for British participants at 2- and 4-year follow-up respectively. The effect was greater in younger participants.ConclusionsOnly the most severe syndromes and cases of depression are a risk factor for dementia.Declaration of interestNone. Funding detailed in Acknowledgements.

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    KW - GERIATRIC MENTAL STATE

    KW - OLDER-PEOPLE

    KW - MRC-ALPHA

    KW - COMMUNITY RESIDENTS

    KW - ALZHEIMERS-DISEASE

    KW - POPULATION

    KW - PREVALENCE

    KW - METAANALYSIS

    KW - VALIDATION

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    DO - 10.1192/bjp.bp.107.044974

    M3 - Article

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    SP - 373

    EP - 377

    JO - British Journal of Psychiatry

    JF - British Journal of Psychiatry

    SN - 0007-1250

    IS - 5

    ER -