Shear modulus imaging by direct visualization of propagating shear waves with phase-sensitive optical coherence tomography

Shaozhen Song, Zhihong Huang, Thu-Mai Nguyen, Emily Y. Wong, Bastien Arnal, Matthew O'Donnell, Ruikang K. Wang

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    70 Citations (Scopus)

    Abstract

    We propose an integrated method combining low-frequency mechanics with optical imaging to map the shear modulus within the biological tissue. Induced shear wave propagating in tissue is tracked in space and time using phase-sensitive optical coherence tomography (PhS-OCT). Local estimates of the shear-wave speed obtained from tracking results can image the local shear modulus. A PhS-OCT system remotely records depth-resolved, dynamic mechanical waves at an equivalent frame rate of ~47??kHz with the high spatial resolution. The proposed method was validated by examining tissue-mimicking phantoms made of agar and light scattering material. Results demonstrate that the shear wave imaging can accurately map the elastic moduli of these phantoms.
    Original languageEnglish
    Article number121509
    JournalJournal of Biomedical Optics
    Volume18
    Issue number12
    DOIs
    Publication statusPublished - Dec 2013

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