Shear modulus imaging by direct visualization of propagating shear waves with phase-sensitive optical coherence tomography

Shaozhen Song; Zhihong Huang; Thu-Mai Nguyen; Emily Y. Wong; Bastien Arnal; Matthew O'Donnell; Ruikang K. Wang

doi:10.1117/1.JBO.18.12.121509

Shear modulus imaging by direct visualization of propagating shear waves with phase-sensitive optical coherence tomography

Shaozhen Song
, Zhihong Huang
, Thu-Mai Nguyen
, Emily Y. Wong
, Bastien Arnal
, Matthew O'Donnell
, Ruikang K. Wang

Research output: Contribution to journal › Article › peer-review

114 Citations (Scopus)

Abstract

We propose an integrated method combining low-frequency mechanics with optical imaging to map the shear modulus within the biological tissue. Induced shear wave propagating in tissue is tracked in space and time using phase-sensitive optical coherence tomography (PhS-OCT). Local estimates of the shear-wave speed obtained from tracking results can image the local shear modulus. A PhS-OCT system remotely records depth-resolved, dynamic mechanical waves at an equivalent frame rate of ~47??kHz with the high spatial resolution. The proposed method was validated by examining tissue-mimicking phantoms made of agar and light scattering material. Results demonstrate that the shear wave imaging can accurately map the elastic moduli of these phantoms.

Original language	English
Article number	121509
Journal	Journal of Biomedical Optics
Volume	18
Issue number	12
DOIs	https://doi.org/10.1117/1.JBO.18.12.121509
Publication status	Published - Dec 2013

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title = "Shear modulus imaging by direct visualization of propagating shear waves with phase-sensitive optical coherence tomography",

abstract = "We propose an integrated method combining low-frequency mechanics with optical imaging to map the shear modulus within the biological tissue. Induced shear wave propagating in tissue is tracked in space and time using phase-sensitive optical coherence tomography (PhS-OCT). Local estimates of the shear-wave speed obtained from tracking results can image the local shear modulus. A PhS-OCT system remotely records depth-resolved, dynamic mechanical waves at an equivalent frame rate of \textasciitilde{}47??kHz with the high spatial resolution. The proposed method was validated by examining tissue-mimicking phantoms made of agar and light scattering material. Results demonstrate that the shear wave imaging can accurately map the elastic moduli of these phantoms.",

author = "Shaozhen Song and Zhihong Huang and Thu-Mai Nguyen and Wong, \{Emily Y.\} and Bastien Arnal and Matthew O'Donnell and Wang, \{Ruikang K.\}",

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AU - Song, Shaozhen

AU - Huang, Zhihong

AU - Nguyen, Thu-Mai

AU - Wong, Emily Y.

AU - Arnal, Bastien

AU - O'Donnell, Matthew

AU - Wang, Ruikang K.

PY - 2013/12

Y1 - 2013/12

N2 - We propose an integrated method combining low-frequency mechanics with optical imaging to map the shear modulus within the biological tissue. Induced shear wave propagating in tissue is tracked in space and time using phase-sensitive optical coherence tomography (PhS-OCT). Local estimates of the shear-wave speed obtained from tracking results can image the local shear modulus. A PhS-OCT system remotely records depth-resolved, dynamic mechanical waves at an equivalent frame rate of ~47??kHz with the high spatial resolution. The proposed method was validated by examining tissue-mimicking phantoms made of agar and light scattering material. Results demonstrate that the shear wave imaging can accurately map the elastic moduli of these phantoms.

AB - We propose an integrated method combining low-frequency mechanics with optical imaging to map the shear modulus within the biological tissue. Induced shear wave propagating in tissue is tracked in space and time using phase-sensitive optical coherence tomography (PhS-OCT). Local estimates of the shear-wave speed obtained from tracking results can image the local shear modulus. A PhS-OCT system remotely records depth-resolved, dynamic mechanical waves at an equivalent frame rate of ~47??kHz with the high spatial resolution. The proposed method was validated by examining tissue-mimicking phantoms made of agar and light scattering material. Results demonstrate that the shear wave imaging can accurately map the elastic moduli of these phantoms.

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JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

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M1 - 121509

ER -

Shear modulus imaging by direct visualization of propagating shear waves with phase-sensitive optical coherence tomography

Abstract

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