Shear wave elastography of ex vivo human corneas using phase-sensitive optical coherence tomography

Thu Mai Nguyen, Shaozhen Song, Lei Shi, Ruikang K. Wang, Matthew O'Donnell, Tueng T. Shen, Zhihong Huang

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)

    Abstract

    Assessing the biomechanical properties of the cornea can provide clinically valuable information in addition to structural images for better management of pathologies (e.g. glaucoma) or refractive surgeries. OCT provides a micron scale and high sensitivity that are ideal for ophthalmic applications. We propose a shear wave elastography (SWE) method for the cornea based on phase-sensitive optical coherence tomography (PhS-OCT). SWE consists in launching a propagating shear wave in tissues and retrieving tissue elasticity from the shear wave speed. We used a piezo-electric actuator in contact with the cornea to induce shear waves that were then tracked using a PhSOCT system operating in M-B mode at an equivalent frame rate of 45 kHz. The actuator was driven by a broadband, linear-swept frequency sine. The corresponding displacements were numerically transformed into a short and spatially localized pulse by a pulse compression algorithm. The local shear wave speed was then computed using time-of-flight estimations. We performed experiments on excised human corneas obtained from the eye bank. The corneas were mounted on an artificial anterior chamber in which the IOP could be varied. Elasticity measurements were acquired for IOP ranging from 10 to 40 mmHg. These preliminary studies demonstrate the feasibility of using PhS-OCT for elastography of human corneas. Further studies will aim at developing non-contact shear sources for clinical translation.

    Original languageEnglish
    Title of host publication2014 IEEE International Ultrasonics Symposium, IUS
    PublisherIEEE Computer Society
    Pages217-220
    Number of pages4
    ISBN (Print)9781479970490
    DOIs
    Publication statusPublished - 20 Oct 2014
    Event2014 IEEE International Ultrasonics Symposium, IUS 2014 - Chicago, United States
    Duration: 3 Sep 20146 Sep 2014

    Conference

    Conference2014 IEEE International Ultrasonics Symposium, IUS 2014
    CountryUnited States
    CityChicago
    Period3/09/146/09/14

      Fingerprint

    Keywords

    • chirp
    • cornea
    • phase-sensitive optical coherence tomography
    • pulse compression
    • shear wave elastography

    Cite this

    Nguyen, T. M., Song, S., Shi, L., Wang, R. K., O'Donnell, M., Shen, T. T., & Huang, Z. (2014). Shear wave elastography of ex vivo human corneas using phase-sensitive optical coherence tomography. In 2014 IEEE International Ultrasonics Symposium, IUS (pp. 217-220). [6932156] IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2014.0055