Shear wave elastography using amplitude-modulated acoustic radiation force and phase-sensitive optical coherence tomography

Thu-Mai Nguyen (Lead / Corresponding author), Bastien Arnal, Shaozhen Song, Zhihong Huang, Ruikang K. Wang, Matthew O'Donnell

    Research output: Contribution to journalArticle

    37 Citations (Scopus)

    Abstract

    Investigating the elasticity of ocular tissue (cornea and intraocular lens) could help the understanding and management of pathologies related to biomechanical deficiency. In previous studies, we introduced a setup based on optical coherence tomography for shear wave elastography (SWE) with high resolution and high sensitivity. SWE determines tissue stiffness from the propagation speed of shear waves launched within tissue. We proposed acoustic radiation force to remotely induce shear waves by focusing an ultrasound (US) beam in tissue, similar to several elastography techniques. Minimizing the maximum US pressure is essential in ophthalmology for safety reasons. For this purpose, we propose a pulse compression approach. It utilizes coded US emissions to generate shear waves where the energy is spread over a long emission, and then numerically compressed into a short, localized, and high-energy pulse. We used a 7.5-MHz single-element focused transducer driven by coded excitations where the amplitude is modulated by a linear frequency-swept square wave (1 to 7 kHz). An inverse filter approach was used for compression. We demonstrate the feasibility of performing shear wave elastography measurements in tissue-mimicking phantoms at low US pressures (mechanical index < 0.6)

    Original languageEnglish
    Article number016001
    Number of pages7
    JournalJournal of Biomedical Optics
    Volume20
    Issue number1
    DOIs
    Publication statusPublished - Jan 2015

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