Shear wave elastography using phase sensitive optical coherence tomography

Shaozhen Song, Zhihong Huang, Thu-Mai Nguyen, Emily Y. Wong, Bastien Arnal, Matthew O'Donnell, Ruikang K. Wang

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)

    Abstract

    Optical coherence tomography (OCT) provides high spatial resolution and sensitivity that are ideal for imaging the cornea and lens. Quantifying the biomechanical properties of these tissues could add clinically valuable information. Thus, we propose a dynamic elastography method combining OCT detection and a mechanical actuator to map the shear modulus of soft tissues. We used a piezoelectric actuator driven in the kHz range and we used phase-sensitive OCT (PhS-OCT) to track the resulting shear waves at an equivalent frame rate of 47 kHz. We mapped the shear wave speed of anesthetized mice cornea using monochromatic excitations. We found a significant difference between a group of knock-out (3.92 ± 0.35 m/s, N=4) and wild-type mice (5.04 ± 0.51 m/s, N=3). These preliminary results demonstrate the feasibility of using PhS-OCT to perform in vivo shear wave elastography of the cornea. We then implemented a shear pulse compression approach on ex vivo human cornea. For that purpose, frequency- modulated excitations were used and the resulting displacement field was digitally compressed in a short broadband pulse with a 7 dB gain in signal-to-noise ratio (SNR).

    Original languageEnglish
    Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII
    PublisherSPIE-International Society for Optical Engineering
    ISBN (Print)9780819498472
    DOIs
    Publication statusPublished - 4 Mar 2014
    EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII - San Francisco, CA, United States
    Duration: 3 Feb 20145 Feb 2014

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume8934
    ISSN (Print)1605-7422

    Conference

    ConferenceOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII
    CountryUnited States
    CitySan Francisco, CA
    Period3/02/145/02/14

    Keywords

    • Cornea
    • Phase-sensitive optical coherence tomography
    • Pulse compression
    • Shear wave elastography

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