Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography

Thu-Mai Nguyen (Lead / Corresponding author), Shaozhen Song, Bastien Arnal, Emily Y. Wong, Zhihong Huang, Ruikang K. Wang, Matthew O'Donnell

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    ABSTRACT. Assessing the biomechanical properties of soft tissue provides clinically valuable information to supplement conventional structural imaging. In the previous studies, we introduced a dynamic elastography technique based on phase-sensitive optical coherence tomography (PhS-OCT) to characterize submillimetric structures such as skin layers or ocular tissues. Here, we propose to implement a pulse compression technique for shear wave elastography. We performed shear wave pulse compression in tissue-mimicking phantoms. Using a mechanical actuator to generate broadband frequency-modulated vibrations (1 to 5 kHz), induced displacements were detected at an equivalent frame rate of 47 kHz using a PhS-OCT. The recorded signal was digitally compressed to a broadband pulse. Stiffness maps were then reconstructed from spatially localized estimates of the local shear wave speed. We demonstrate that a simple pulse compression scheme can increase shear wave detection signal-to-noise ratio (>12 dB gain) and reduce artifacts in reconstructing stiffness maps of heterogeneous media.

    Original languageEnglish
    Article number016013
    Number of pages7
    JournalJournal of Biomedical Optics
    Issue number1
    Early online date17 Jan 2014
    Publication statusPublished - Jan 2014


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