Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography

Thu-Mai Nguyen (Lead / Corresponding author), Shaozhen Song, Bastien Arnal, Emily Y. Wong, Zhihong Huang, Ruikang K. Wang, Matthew O'Donnell

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    Abstract

    ABSTRACT. Assessing the biomechanical properties of soft tissue provides clinically valuable information to supplement conventional structural imaging. In the previous studies, we introduced a dynamic elastography technique based on phase-sensitive optical coherence tomography (PhS-OCT) to characterize submillimetric structures such as skin layers or ocular tissues. Here, we propose to implement a pulse compression technique for shear wave elastography. We performed shear wave pulse compression in tissue-mimicking phantoms. Using a mechanical actuator to generate broadband frequency-modulated vibrations (1 to 5 kHz), induced displacements were detected at an equivalent frame rate of 47 kHz using a PhS-OCT. The recorded signal was digitally compressed to a broadband pulse. Stiffness maps were then reconstructed from spatially localized estimates of the local shear wave speed. We demonstrate that a simple pulse compression scheme can increase shear wave detection signal-to-noise ratio (>12 dB gain) and reduce artifacts in reconstructing stiffness maps of heterogeneous media.

    Original languageEnglish
    Article number016013
    Number of pages7
    JournalJournal of Biomedical Optics
    Volume19
    Issue number1
    Early online date17 Jan 2014
    DOIs
    Publication statusPublished - Jan 2014

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