Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography

TY - JOUR

T1 - Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography

AU - Nguyen, Thu-Mai

AU - Song, Shaozhen

AU - Arnal, Bastien

AU - Wong, Emily Y.

AU - Huang, Zhihong

AU - Wang, Ruikang K.

AU - O'Donnell, Matthew

PY - 2014/1

Y1 - 2014/1

N2 - ABSTRACT. Assessing the biomechanical properties of soft tissue provides clinically valuable information to supplement conventional structural imaging. In the previous studies, we introduced a dynamic elastography technique based on phase-sensitive optical coherence tomography (PhS-OCT) to characterize submillimetric structures such as skin layers or ocular tissues. Here, we propose to implement a pulse compression technique for shear wave elastography. We performed shear wave pulse compression in tissue-mimicking phantoms. Using a mechanical actuator to generate broadband frequency-modulated vibrations (1 to 5 kHz), induced displacements were detected at an equivalent frame rate of 47 kHz using a PhS-OCT. The recorded signal was digitally compressed to a broadband pulse. Stiffness maps were then reconstructed from spatially localized estimates of the local shear wave speed. We demonstrate that a simple pulse compression scheme can increase shear wave detection signal-to-noise ratio (>12 dB gain) and reduce artifacts in reconstructing stiffness maps of heterogeneous media.

AB - ABSTRACT. Assessing the biomechanical properties of soft tissue provides clinically valuable information to supplement conventional structural imaging. In the previous studies, we introduced a dynamic elastography technique based on phase-sensitive optical coherence tomography (PhS-OCT) to characterize submillimetric structures such as skin layers or ocular tissues. Here, we propose to implement a pulse compression technique for shear wave elastography. We performed shear wave pulse compression in tissue-mimicking phantoms. Using a mechanical actuator to generate broadband frequency-modulated vibrations (1 to 5 kHz), induced displacements were detected at an equivalent frame rate of 47 kHz using a PhS-OCT. The recorded signal was digitally compressed to a broadband pulse. Stiffness maps were then reconstructed from spatially localized estimates of the local shear wave speed. We demonstrate that a simple pulse compression scheme can increase shear wave detection signal-to-noise ratio (>12 dB gain) and reduce artifacts in reconstructing stiffness maps of heterogeneous media.

UR - http://www.scopus.com/record/display.uri?eid=2-s2.0-84897586216&origin=resultslist&sort=plf-f&src=s&st1=Shear+wave+pulse+compression+for+dynamic+elastography+using+phase-sensitive+optical+coherence+tomography&st2=&sid=BFBEF1F804D20D7282D119A4610F5744.53bsOu7mi7A1NSY7fPJf1g%3a1200&sot=b&sdt=b&sl=119&s=TITLE-ABS-KEY%28Shear+wave+pulse+compression+for+dynamic+elastography+using+phase-sensitive+optical+coherence+tomography%29&relpos=0&citeCnt=13&searchTerm=

U2 - 10.1117/1.JBO.19.1.016013

DO - 10.1117/1.JBO.19.1.016013

M3 - Article

C2 - 24441876

SN - 1083-3668

VL - 19

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

IS - 1

M1 - 016013

ER -