Should ICSI be the treatment of choice for all cases of in-vitro conception? Considerations of fertilization and embryo development, cost effectiveness and safety

Bolarinde Ola, Masoud Afnan, Khaldoun Sharif, Spyros Papaioannou, Nahed Hammadieh, Christopher L.R. Barratt (Lead / Corresponding author)

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

There is now considerable discussion whether intracytoplasmic sperm injection (ICSI) should be used in all cases of IVF. A critical and balanced view of the current literature is presented. The difficult question is how to identify men with apparently normal semen who are likely to fail to achieve a pregnancy using IVF. In conclusion, from both the safety and scientific viewpoint, ICSI should only be used in cases where success at IVF is regarded as unlikely.

Original languageEnglish
Pages (from-to)2485-2490
Number of pages6
JournalHuman Reproduction
Volume16
Issue number12
DOIs
Publication statusPublished - 1 Dec 2001

Keywords

  • Blastocyst/physiology
  • Cost-Benefit Analysis
  • Embryo, Mammalian/physiology
  • Female
  • Humans
  • Infertility, Male/therapy
  • Male
  • Pregnancy
  • Pregnancy Outcome
  • Safety
  • Sperm Injections, Intracytoplasmic/adverse effects

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