Should ICSI be the treatment of choice for all cases of in-vitro conception?: Considerations of fertilization and embryo development, cost effectiveness and safety

Bolarinde Ola; Masoud Afnan; Khaldoun Sharif; Spyros Papaioannou; Nahed Hammadieh; Christopher L.R. Barratt

doi:10.1093/humrep/16.12.2485

Should ICSI be the treatment of choice for all cases of in-vitro conception? Considerations of fertilization and embryo development, cost effectiveness and safety

Bolarinde Ola, Masoud Afnan, Khaldoun Sharif, Spyros Papaioannou, Nahed Hammadieh, Christopher L.R. Barratt (Lead / Corresponding author)

Undergraduate Medicine

Research output: Contribution to journal › Review article › peer-review

70 Citations (Scopus)

Abstract

There is now considerable discussion whether intracytoplasmic sperm injection (ICSI) should be used in all cases of IVF. A critical and balanced view of the current literature is presented. The difficult question is how to identify men with apparently normal semen who are likely to fail to achieve a pregnancy using IVF. In conclusion, from both the safety and scientific viewpoint, ICSI should only be used in cases where success at IVF is regarded as unlikely.

Original language	English
Pages (from-to)	2485-2490
Number of pages	6
Journal	Human Reproduction
Volume	16
Issue number	12
DOIs	https://doi.org/10.1093/humrep/16.12.2485
Publication status	Published - 1 Dec 2001

Keywords

Blastocyst/physiology
Cost-Benefit Analysis
Embryo, Mammalian/physiology
Female
Humans
Infertility, Male/therapy
Male
Pregnancy
Pregnancy Outcome
Safety
Sperm Injections, Intracytoplasmic/adverse effects

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10.1093/humrep/16.12.2485

Cite this

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title = "Should ICSI be the treatment of choice for all cases of in-vitro conception?: Considerations of fertilization and embryo development, cost effectiveness and safety",

abstract = "There is now considerable discussion whether intracytoplasmic sperm injection (ICSI) should be used in all cases of IVF. A critical and balanced view of the current literature is presented. The difficult question is how to identify men with apparently normal semen who are likely to fail to achieve a pregnancy using IVF. In conclusion, from both the safety and scientific viewpoint, ICSI should only be used in cases where success at IVF is regarded as unlikely.",

keywords = "Blastocyst/physiology, Cost-Benefit Analysis, Embryo, Mammalian/physiology, Female, Humans, Infertility, Male/therapy, Male, Pregnancy, Pregnancy Outcome, Safety, Sperm Injections, Intracytoplasmic/adverse effects",

author = "Bolarinde Ola and Masoud Afnan and Khaldoun Sharif and Spyros Papaioannou and Nahed Hammadieh and Barratt, \{Christopher L.R.\}",

year = "2001",

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doi = "10.1093/humrep/16.12.2485",

language = "English",

volume = "16",

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journal = "Human Reproduction",

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T1 - Should ICSI be the treatment of choice for all cases of in-vitro conception?

T2 - Considerations of fertilization and embryo development, cost effectiveness and safety

AU - Ola, Bolarinde

AU - Afnan, Masoud

AU - Sharif, Khaldoun

AU - Papaioannou, Spyros

AU - Hammadieh, Nahed

AU - Barratt, Christopher L.R.

PY - 2001/12/1

Y1 - 2001/12/1

N2 - There is now considerable discussion whether intracytoplasmic sperm injection (ICSI) should be used in all cases of IVF. A critical and balanced view of the current literature is presented. The difficult question is how to identify men with apparently normal semen who are likely to fail to achieve a pregnancy using IVF. In conclusion, from both the safety and scientific viewpoint, ICSI should only be used in cases where success at IVF is regarded as unlikely.

AB - There is now considerable discussion whether intracytoplasmic sperm injection (ICSI) should be used in all cases of IVF. A critical and balanced view of the current literature is presented. The difficult question is how to identify men with apparently normal semen who are likely to fail to achieve a pregnancy using IVF. In conclusion, from both the safety and scientific viewpoint, ICSI should only be used in cases where success at IVF is regarded as unlikely.

KW - Blastocyst/physiology

KW - Cost-Benefit Analysis

KW - Embryo, Mammalian/physiology

KW - Female

KW - Humans

KW - Infertility, Male/therapy

KW - Male

KW - Pregnancy

KW - Pregnancy Outcome

KW - Safety

KW - Sperm Injections, Intracytoplasmic/adverse effects

U2 - 10.1093/humrep/16.12.2485

DO - 10.1093/humrep/16.12.2485

M3 - Review article

C2 - 11726563

SN - 0268-1161

VL - 16

SP - 2485

EP - 2490

JO - Human Reproduction

JF - Human Reproduction

IS - 12

ER -

Should ICSI be the treatment of choice for all cases of in-vitro conception? Considerations of fertilization and embryo development, cost effectiveness and safety

Abstract

Keywords

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