Sialoadhesin in recognition of self and non-self

Mariliis Klaas, Paul R. Crocker

    Research output: Contribution to journalReview article

    48 Citations (Scopus)

    Abstract

    The immune system is tightly regulated to maintain an appropriate balance between immune activation and tolerance. Macrophages play a key role in this process since they express many pathogen recognition molecules as well as receptors for 'self'. Sialoadhesin is a major macrophage receptor that specifically recognizes sialic acid, an abundant component of host glycoconjugates but which can also be found on several human pathogens. In recent years, several studies have demonstrated that sialoadhesin can contribute to the uptake and processing of sialylated pathogens as well as playing an important role in regulating inflammatory and autoimmune responses via recognition of self.

    Original languageEnglish
    Pages (from-to)353-364
    Number of pages12
    JournalSeminars in Immunopathology
    Volume34
    Issue number3
    DOIs
    Publication statusPublished - 2012

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