Sialylation and immune surveillance of cancer by siglecs

Paul R. Crocker, Bindu Mohan

Research output: Chapter in Book/Report/Conference proceedingChapter


Changes in cell surface glycosylation are a key feature of cancer initiation and progression. Sialic acid is a major glycan attached to extracellular proteins and lipids. Altered sialylation in cancer can impact at many levels and may result in improved cancer cell survival and spread. Here we focus on sialic acid-dependent interactions of tumour cells with sialic acid-binding Ig-like lectins (siglecs). These proteins are expressed broadly in the immune system and can modulate cellular functions in diverse ways. We discuss changes in sialylation commonly observed in tumours and the emerging role of siglecs in modulating both host immune responses and tumour responses.

Original languageEnglish
Title of host publicationGlycosignals in Cancer: Mechanisms of Malignant Phenotypes
PublisherSpringer Japan
Number of pages14
ISBN (Print)9784431559399, 9784431559375
Publication statusPublished - 27 Jan 2016


  • Cancer
  • Glycosylation
  • Immune system
  • Lectins
  • Sialic acid
  • Siglec

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Medicine


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