Sialylation and immune surveillance of cancer by siglecs

Paul R. Crocker; Bindu Mohan

doi:10.1007/978-4-431-55939-9_8

Sialylation and immune surveillance of cancer by siglecs

Paul R. Crocker, Bindu Mohan

Cell Signalling and Immunology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Changes in cell surface glycosylation are a key feature of cancer initiation and progression. Sialic acid is a major glycan attached to extracellular proteins and lipids. Altered sialylation in cancer can impact at many levels and may result in improved cancer cell survival and spread. Here we focus on sialic acid-dependent interactions of tumour cells with sialic acid-binding Ig-like lectins (siglecs). These proteins are expressed broadly in the immune system and can modulate cellular functions in diverse ways. We discuss changes in sialylation commonly observed in tumours and the emerging role of siglecs in modulating both host immune responses and tumour responses.

Original language	English
Title of host publication	Glycosignals in Cancer: Mechanisms of Malignant Phenotypes
Publisher	Springer Japan
Pages	125-138
Number of pages	14
ISBN (Print)	9784431559399, 9784431559375
DOIs	https://doi.org/10.1007/978-4-431-55939-9_8
Publication status	Published - 27 Jan 2016

Keywords

Cancer
Glycosylation
Immune system
Lectins
Sialic acid
Siglec

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology
General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-4-431-55939-9_8

Cite this

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KW - Glycosylation

KW - Immune system

KW - Lectins

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Sialylation and immune surveillance of cancer by siglecs

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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