Siglec-mediated regulation of immune cell function in disease

Matthew S. Macauley; Paul R. Crocker; James C. Paulson

doi:10.1038/nri3737

Siglec-mediated regulation of immune cell function in disease

Matthew S. Macauley
, Paul R. Crocker
, James C. Paulson (Lead / Corresponding author)

Research output: Contribution to journal › Article › peer-review

948 Citations (Scopus)

Abstract

All mammalian cells display a diverse array of glycan structures that differ from those that are found on microbial pathogens. Siglecs are a family of sialic acid-binding immunoglobulin-like receptors that participate in the discrimination between self and non-self, and that regulate the function of cells in the innate and adaptive immune systems through the recognition of their glycan ligands. In this Review, we describe the recent advances in our understanding of the roles of Siglecs in the regulation of immune cell function in infectious diseases, inflammation, neurodegeneration, autoimmune diseases and cancer.

Original language	English
Pages (from-to)	653-666
Number of pages	14
Journal	Nature Reviews Immunology
Volume	14
Issue number	10
DOIs	https://doi.org/10.1038/nri3737
Publication status	Published - Oct 2014

UN SDGs

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SDG 3 Good Health and Well-being

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Cite this

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Siglec-mediated regulation of immune cell function in disease

Abstract

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