Siglecs and their roles in the immune system

Paul R. Crocker; James C. Paulson; Ajit Varki

doi:10.1038/nri2056

Siglecs and their roles in the immune system

Paul R. Crocker, James C. Paulson, Ajit Varki

Research output: Contribution to journal › Article › peer-review

1629 Citations (Scopus)

Abstract

Cell surfaces in the immune system are richly equipped with a complex mixture of glycans, which can be recognized by diverse glycan-binding proteins. The Siglecs are a family of sialic-acid-binding immunoglobulin-like lectins that are thought to promote cell-cell interactions and regulate the functions of cells in the innate and adaptive immune systems through glycan recognition. In this Review, we describe recent studies on signalling mechanisms and discuss the potential role of Siglecs in triggering endocytosis and in pathogen recognition. Finally, we discuss the postulated functions of the recently discovered CD33-related Siglecs and consider the factors that seem to be driving their rapid evolution.

Original language	English
Pages (from-to)	255-266
Number of pages	12
Journal	Nature Reviews Immunology
Volume	7
Issue number	4
DOIs	https://doi.org/10.1038/nri2056
Publication status	Published - Apr 2007

Keywords

Animals
Antigens, CD
Antigens, Differentiation, Myelomonocytic
Cell Communication
Endocytosis
Humans
Lectins
Lymphocyte Activation
Lymphocytes
N-Acetylneuraminic Acid
Protein Structure, Tertiary
Sialic Acid Binding Ig-like Lectin 2
Sialic Acid Binding Ig-like Lectin 3
Sialic Acid Binding Immunoglobulin-like Lectins
Signal Transduction

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abstract = "Cell surfaces in the immune system are richly equipped with a complex mixture of glycans, which can be recognized by diverse glycan-binding proteins. The Siglecs are a family of sialic-acid-binding immunoglobulin-like lectins that are thought to promote cell-cell interactions and regulate the functions of cells in the innate and adaptive immune systems through glycan recognition. In this Review, we describe recent studies on signalling mechanisms and discuss the potential role of Siglecs in triggering endocytosis and in pathogen recognition. Finally, we discuss the postulated functions of the recently discovered CD33-related Siglecs and consider the factors that seem to be driving their rapid evolution.",

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AU - Paulson, James C.

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KW - Antigens, CD

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KW - Cell Communication

KW - Endocytosis

KW - Humans

KW - Lectins

KW - Lymphocyte Activation

KW - Lymphocytes

KW - N-Acetylneuraminic Acid

KW - Protein Structure, Tertiary

KW - Sialic Acid Binding Ig-like Lectin 2

KW - Sialic Acid Binding Ig-like Lectin 3

KW - Sialic Acid Binding Immunoglobulin-like Lectins

KW - Signal Transduction

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JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

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Siglecs and their roles in the immune system

Abstract

Keywords

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