Projects per year
Abstract
The discovery of interleukin-2 (IL-2) changed the molecular understanding of how the immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling pathways that allow IL-2 to control the differentiation and homeostasis of both pro- and anti-inflammatory T cells is fundamental to determining the molecular details of immune regulation. The IL-2 receptor couples to JAK tyrosine kinases and activates the STAT5 transcription factors. However, IL-2 does much more than control transcriptional programs; it is a key regulator of T cell metabolic programs. The development of global phosphoproteomic approaches has expanded the understanding of IL-2 signaling further, revealing the diversity of phosphoproteins that may be influenced by IL-2 in T cells. However, it is increasingly clear that within each T cell subset, IL-2 will signal within a framework of other signal transduction networks that together will shape the transcriptional and metabolic programs that determine T cell fate.
Original language | English |
---|---|
Pages (from-to) | 411-433 |
Number of pages | 23 |
Journal | Annual Review of Immunology |
Volume | 36 |
DOIs | |
Publication status | Published - 26 Apr 2018 |
Keywords
- Interleukin-2
- JAK1/3
- PI3K
- cytokine signaling
Fingerprint
Dive into the research topics of 'Signaling and Function of Interleukin-2 in T Lymphocytes'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Serine Kinase Pathways that Determine T Lymphocyte Activation and Cell Fate Choices (Principal Research Fellowship renewal)
Cantrell, D. (Investigator)
1/10/12 → 1/10/24
Project: Research