Signaling in lymphocyte activation

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)


The fate of T and B lymphocytes, the key cells that direct the adaptive immune response, is regulated by a diverse network of signal transduction pathways. The T- and B-cell antigen receptors are coupled to intracellular tyrosine kinases and adaptor molecules to control the metabolism of inositol phospholipids and calcium release. The production of inositol poly-phosphates and lipid second messengers directs the activity of downstream guanine-nucleo-tide-binding proteins and protein and lipid kinases/phosphatases that control lymphocyte transcriptional and metabolic programs. Lymphocyte activation is modulated bycostimulatory molecules and cytokines that elicit intracellular signaling that is integrated with the antigen-receptor-controlled pathways.

Original languageEnglish
Article numbera018788
Number of pages14
JournalCold spring harbor perspectives in biology
Issue number6
Publication statusPublished - Jun 2015

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


Dive into the research topics of 'Signaling in lymphocyte activation'. Together they form a unique fingerprint.

Cite this