Signaling in lymphocyte activation

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The fate of T and B lymphocytes, the key cells that direct the adaptive immune response, is regulated by a diverse network of signal transduction pathways. The T- and B-cell antigen receptors are coupled to intracellular tyrosine kinases and adaptor molecules to control the metabolism of inositol phospholipids and calcium release. The production of inositol poly-phosphates and lipid second messengers directs the activity of downstream guanine-nucleo-tide-binding proteins and protein and lipid kinases/phosphatases that control lymphocyte transcriptional and metabolic programs. Lymphocyte activation is modulated bycostimulatory molecules and cytokines that elicit intracellular signaling that is integrated with the antigen-receptor-controlled pathways.

Original languageEnglish
Article numbera018788
Number of pages14
JournalCold spring harbor perspectives in biology
Volume7
Issue number6
DOIs
Publication statusPublished - Jun 2015

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Lymphocytes
Lymphocyte Activation
Chemical activation
Lipids
B-Cell Antigen Receptors
Antigen Receptors
Inositol Phosphates
Guanine
Second Messenger Systems
Adaptive Immunity
T-Cell Antigen Receptor
Phosphatidylinositols
Phosphoric Monoester Hydrolases
Protein-Tyrosine Kinases
Protein Kinases
Signal Transduction
Signal transduction
Carrier Proteins
Molecules
B-Lymphocytes

Cite this

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title = "Signaling in lymphocyte activation",
abstract = "The fate of T and B lymphocytes, the key cells that direct the adaptive immune response, is regulated by a diverse network of signal transduction pathways. The T- and B-cell antigen receptors are coupled to intracellular tyrosine kinases and adaptor molecules to control the metabolism of inositol phospholipids and calcium release. The production of inositol poly-phosphates and lipid second messengers directs the activity of downstream guanine-nucleo-tide-binding proteins and protein and lipid kinases/phosphatases that control lymphocyte transcriptional and metabolic programs. Lymphocyte activation is modulated bycostimulatory molecules and cytokines that elicit intracellular signaling that is integrated with the antigen-receptor-controlled pathways.",
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Signaling in lymphocyte activation. / Cantrell, Doreen.

In: Cold spring harbor perspectives in biology, Vol. 7, No. 6, a018788, 06.2015.

Research output: Contribution to journalArticle

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