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Abstract
The fate of T and B lymphocytes, the key cells that direct the adaptive immune response, is regulated by a diverse network of signal transduction pathways. The T- and B-cell antigen receptors are coupled to intracellular tyrosine kinases and adaptor molecules to control the metabolism of inositol phospholipids and calcium release. The production of inositol poly-phosphates and lipid second messengers directs the activity of downstream guanine-nucleo-tide-binding proteins and protein and lipid kinases/phosphatases that control lymphocyte transcriptional and metabolic programs. Lymphocyte activation is modulated bycostimulatory molecules and cytokines that elicit intracellular signaling that is integrated with the antigen-receptor-controlled pathways.
Original language | English |
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Article number | a018788 |
Number of pages | 14 |
Journal | Cold spring harbor perspectives in biology |
Volume | 7 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2015 |