Abstract
The fate of T and B lymphocytes, the key cells that direct the adaptive immune response, is regulated by a diverse network of signal transduction pathways. The T- and B-cell antigen receptors are coupled to intracellular tyrosine kinases and adaptor molecules to control the metabolism of inositol phospholipids and calcium release. The production of inositol poly-phosphates and lipid second messengers directs the activity of downstream guanine-nucleo-tide-binding proteins and protein and lipid kinases/phosphatases that control lymphocyte transcriptional and metabolic programs. Lymphocyte activation is modulated bycostimulatory molecules and cytokines that elicit intracellular signaling that is integrated with the antigen-receptor-controlled pathways.
| Original language | English |
|---|---|
| Article number | a018788 |
| Number of pages | 14 |
| Journal | Cold spring harbor perspectives in biology |
| Volume | 7 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2015 |
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Signaling in lymphocyte activation. / Cantrell, Doreen.
In: Cold spring harbor perspectives in biology, Vol. 7, No. 6, a018788, 06.2015.Research output: Contribution to journal › Article
TY - JOUR
T1 - Signaling in lymphocyte activation
AU - Cantrell, Doreen
PY - 2015/6
Y1 - 2015/6
N2 - The fate of T and B lymphocytes, the key cells that direct the adaptive immune response, is regulated by a diverse network of signal transduction pathways. The T- and B-cell antigen receptors are coupled to intracellular tyrosine kinases and adaptor molecules to control the metabolism of inositol phospholipids and calcium release. The production of inositol poly-phosphates and lipid second messengers directs the activity of downstream guanine-nucleo-tide-binding proteins and protein and lipid kinases/phosphatases that control lymphocyte transcriptional and metabolic programs. Lymphocyte activation is modulated bycostimulatory molecules and cytokines that elicit intracellular signaling that is integrated with the antigen-receptor-controlled pathways.
AB - The fate of T and B lymphocytes, the key cells that direct the adaptive immune response, is regulated by a diverse network of signal transduction pathways. The T- and B-cell antigen receptors are coupled to intracellular tyrosine kinases and adaptor molecules to control the metabolism of inositol phospholipids and calcium release. The production of inositol poly-phosphates and lipid second messengers directs the activity of downstream guanine-nucleo-tide-binding proteins and protein and lipid kinases/phosphatases that control lymphocyte transcriptional and metabolic programs. Lymphocyte activation is modulated bycostimulatory molecules and cytokines that elicit intracellular signaling that is integrated with the antigen-receptor-controlled pathways.
UR - http://www.scopus.com/inward/record.url?scp=84930440481&partnerID=8YFLogxK
U2 - 10.1101/cshperspect.a018788
DO - 10.1101/cshperspect.a018788
M3 - Article
C2 - 26032717
AN - SCOPUS:84930440481
VL - 7
JO - Cold spring harbor perspectives in biology
JF - Cold spring harbor perspectives in biology
SN - 1943-0264
IS - 6
M1 - a018788
ER -